جستجوی مقالات مرتبط با کلیدواژه « هیپرلیپدمی » در نشریات گروه « پزشکی »

Hyperlipidemia is one of the most important factors in heart disease and mortality worldwide. Previous studies showed that flaxseeds included potencies to improve lipid profiles. The objective of the present study was to investigate effects of breads containing flaxseeds on serum levels of apelin and lipids in hyperlipidemic patients.

This study was a randomized controlled clinical trial study with 48 hyperlipidemic patients for six weeks. Patients were randomly divided into two intervention and control groups. The intervention group received two breads containing 20% of flaxseeds and the control group received plain breads every day. Lipid profile, apelin serum, blood pressure and anthropocentric indices of the volunteers were assessed at the beginning and the end of activities and food intakes of the two groups were recorded.

In the intervention group, serum apelin increased (p = 0.02), compared to the control group and cholesterol (p=0.046), triglycerides (p = 0.04) and blood pressure (p = 0/04) significantly decreased, compared to the control group. No significant differences were seen for body mass index,  weight and serum levels of LDL-C and HDL-C between the two groups. Serum apelin increased (255.9 pg/ml), compared to the beginning of the intervention. Moreover, cholesterol, triglycerides and systolic and diastolic blood pressures respectively decreased as 11.2 mg/dl, 19.9 mg/dl, 7.1 mmHg and 10 mmHg, compared to the beginning of the intervention.

Based on the findings, consumption of flaxseed breads included beneficial effects on increasing apelin and decreasing cholesterol, triglycerides and blood pressure. Further studies on flaxseed breads as useful therapeutic foods for decreasing hyperlipidemia are recommended.

Cell Blood Count (CBC) are performed with automatic analysers in laboratories.It works based on three principles electrical impedance, scatter light and flowcytometry. Many factors might affect results by these machines. This study was performed to assay the effect of some confounders on the results of analysers that work based on electrical resistance. This analytical study (case- control) was conducted on 243 persons with hyperglycemia and hyperlipidemia and 100 healthy persosn (control group) in Fateme Zahra Hospital in North of Iran, Golestan. First, Blood glucose and triglyceride were measured with biochemical analyser and CBC was performed for each person. Finally, Statistical analysis and comparison between two groups were performed with SPSS software.Resuts: Comparison between case and control group was shown that both hyperlipidemia and hyperglycemia cause increase in Mean Cell Volume (MCV) and also hyperlipidemia can cause increase in Mean Cell Hemoglobin Concentration (MCHC), Hemoglobin and Hematocrit (Hct) with (P<0.05) According to this study, confounding factors such as hyperglycemia and hyperlipidemia can affect the results of analysers that work based on electrical impedance and it should be considered in laboratories.

Fibrosarcoma is a tumor with mesenchymal cell origin that is composed of malignant fibroblastic cell in a collagen background. Specific treatments for fibrosarcoma, such as chemotherapy, radiation therapy and surgery have many complications for patients. Anti-tumor properties of lycopene have been proved in some types of cancers. In this study we aimed to carry out a research to investigate the effect of tomato extract on the growth of WEHI-164 fibrosarcoma cell in Balb/c mice. Three groups of 10 male Balb/c mice at 8 weeks of age were selected. All three groups were subcutaneously injected with 500000 WEHI-164 tumor cells on day zero in the chest area of the animals. Mice in prevention group were given tomato juice orally, 5 mg/mouse/day for a period of 4 weeks (2 weeks before and 2 week after tumor cell injection). In treatment group, animals were given tomato extract from the day of tumor cell injection (day 0) to two weeks after. Control group did not receive tomato extract. In every individual mouse, the tumor size was measured every 2 days from day 10 (days 10, 12, 14, 16, 18, 20 and 22). Data were statistically analyzed using Kruskal-Wallis and Mann-Whitney tests. The tumor area in control group were significantly larger than two case groups (P<0.05). No significant difference was shown between prevention and treatment groups (P>0.05). With emphasize on anti-tumor effect of tomato, it seems that tomato extract has important role in prevention and control of fibrosarcoma. Since we did not find any differences between treatment and prevention groups to control fibrosarcoma, we recommend further study with different doses of tomato and other types of cancers.