جستجوی مقالات مرتبط با کلیدواژه « پسته وحشی » در نشریات گروه « پزشکی »

Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica on histopathology and liver and kidney function indicators in busulfan-induced liver and kidney injuries in adult mice.

A total of 28 BALB/c mice were randomly divided into four groups (control, busulfan, bene and bene+busulfan). The busulfan group received 10 mg/kg busulfan as a single dose and intraperitoneally. The bene group received plate containing 10% of bene for 35 days. The bene+busulfan group received 10 mg/kg busulfan+10% bene. Then, liver enzymes alanine amino transferase, aspartate amino transferase, urea, creatinine and histopathology of liver and kidney investigated.

The mean urea (P= 0.009) and creatinine level (P= 0.02) in the busulfan group was 55.2±4.23 and 0.8±0.11 mg/dl that it was significantly higher than the bene + busulfan. A significant decrease in ALT level in the bene + busulfan group compared to the busulfan treated group (P= 0.03). In the bene treated group steatosis, necrosis and fibrosis in the liver parenchyma and glomerular sclerosis, inflammation and tubular atrophy in kidney tissue, was not observed.

The results of present study indicated that administration of 10% bene for 35 days improved histopathology of kidney and liver as well as functional index of liver and kidney after renal-liver injury.

Biofilm formation is one of the most notable mechanisms that helped antibiotic resistance in Pseudomonas aeruginosa , The aim of this study were effects of methanol extracts of Quercus brantii jaft, Pistacia atlantica, Elaeagnus angustifolia Leaves on biofilm formation Pseudomonas aeruginosa strains.
this study is an experimental study, that extraction with Maceration(powder mixed with 80% methanol ) and rotary evaporator were done. The minimum inhibitory concentration extracts were done by broth microdilution. biofilm formation by microtiter plate method and stained with crystal violet was used. Data collection were analyzed by SPSS software.
The minimum inhibitory concentration Quercus brantii jaft, Pistacia atlantica, Elaeagnus angustifolia extracts against Pseudomonas aeruginosa showed .625 mg/ml , the Minimum bactericidal concentration of Quercus brantii jaft 1.25 mg ml and for Pistacia atlantica, Elaeagnus angustifolia showed 2.5 mg ml. average percent of Pseudomonas aeruginosa biofilm inhibition by extracts of Quercus brantii jaft, Pistacia atlantica, Elaeagnus angustifolia were 60.24, 57.35, 72.63 % Respectively
Methanolic extracts of medicinal plants Quercus brantii, Pistacia atlantica, Elaeagnus angustifolia It has anti-bacterial and anti-biofilm effect Were against Pseudomonas aeruginosa So that Elaeagnus angustifolia extract Better ability to inhibit biofilm was and to extracts of Quercus brantii jaft, Pistacia atlantica significant differences Showed and in the future we can used thes extract with more work as complementary with antibiotics.

Bachground: Diabetic foot is the most common complication of hospitalization in diabetic patients. The use of herbal products for the relief of diabetic foot in developing countries have acquired considerable acceptance. This study was conducted to evaluate the effect of Pistacia atlantica (local name “Bane”) for the treatment of diabetic foot.
This double-blind randomized clinical trial study was conducted on patients (n=60) with diabetic foot in Beheshti hospital (Kashan, Iran) during 1388-1394. The participants were divided into two equal Intervention and Control groups. The wound dressing in Control and Intervention groups were done using the placebo and “Bane” ointment. Both groups were underwent the conventional (bandages and antibiotic) therapy. Afterwards, the wound characteristics and the duration of wound recovery were assessed in both groups.
The Mean for hospital stay and recovery in intervention (13.8 compared to 33.7 days, respectively) and control groups (22.7 compared to 44.6 days, respectively) was statistically significant (P The “Bane” extract inhibits the growth of some groups of bacteria in diabetic foot ulcers and hence reduces the recovery time and hospital stay.

Due to increased public interest in the use of herbal medicine, their efficacy and safety evaluation have become important. In some studies, Pistacia atlantica leave (PAL) extract suggested as a hypoglycemic agent. However, there is no study about its effects on diabetic nephropathy. Therefore, the present work was conducted to evaluate the effects of aqueous extract of PAL on some biochemical and pathological aspects related to renal function in diabetic rats.
In the present experimental study, 40 severe diabetes male Wistar rats (180-200 gr) with STZ and eight healthy rats at the same age were equally divided into 6 groups and followed for a period of thirty days as the oral treatment respectively. Diabetic groups I ,II and III received 100, 200 and 400 mg/kg of PAL extracts, diabetic group IV received 50 mg/kg Captopril and diabetic group V and healthy group received saline 0.9% as control groups. Finally, fasting blood glucose (FBG), Urine volume and 24 h urine total protein (UTP), blood nitrogen urea (BUN) and plasma creatinine (Cr) were assessed biochemically and also qualitative renal histomorphological alterations were assessed pathologically. Data were analyzed using one-way ANOVA and Tukey post hoc test.
In diabetic control group the FBS (383.5 ± 118.33), BUN (27.17± 2.86), Cr (1.3 ± 0.45), Urine volume (24.66± 5.10) and UTP (25.67 ± 1.51) of groups 1-5 significantly increased in comparison whit normal control group (p The results clearly demonstrate that PAL did not have any beneficial effects on diabetic nephropathy in rats.

Cancer is the most important cause of death worldwide. Natural products and derivatives of medicinal plants can play an important role to cure cancer. The aim of this study was to evaluate the cytotoxic effect of ethanolic extracts of Pistacia Khinjuk leaf on Hela and MCF-7 cell lines. In this laboratory study, ethanolic extract of Pistacia Khinjuk leaves was prepared by using maceration method and its cytotoxic effect on Hela and MCF-7 cell lines was investigated. Hela and MCF-7 cell lines were treated with various concentrations of extract (0.156-10.0 mg/ml) for 72 hours and growth inhibition was assayed using MTT)Methy Thiazol Tetrazolium) test. The optical density of the coloured solution was quantified at 570 nm wavelengths by an ELISA Reader. Data were analyzed using one-way ANOVA and Dunnett's post-test. The results showed that different concentrations of ethanolic extract significantly reduced the growth of Hela and MCF-7 cell lines compared to the control group after 72 hours (P< 0.05). The highest percentages of growth inhibition at concentration of 0.156 mg/ml were 81.33% and 76.76% and the IC50 values were 2.41 and 2.40 mg/ml for Hela and MCF-7 cell lines, respectively. The findings of the present study showed that the ethanolic extract of Pistacia Khinjuk leaf possessed inhibitory effect on Hela and MCF-7 cell lines. In order to find the underlying mechanism of this activity, further research should be carried out.

Hyperlipidemia is one of the factors contributing to cardiovascular disease (CVD). One way of reducing the complications of this disease is the use of medicinal plants. Accordingly, the aim of this study was to evaluate the effect of Pistacia atlantica powder consumption on lipids and other biochemical factors in hyperlipidemic individuals.
This double blind clinical trial was conducted on 60 hyperlipidemic volunteers with blood triglycerides more than 200 mg/dl and cholesterol level over 245 mg/dl. The individuals were randomly divided into two groups, consuming 2.5 (30) and 5 gr (other 30) pistachio powder daily. Before using pistacia powder, fasting blood samples were collected from both groups then, they used pistacia atlantica for two months every day and at the end of study, fasting blood samples were collected again. Blood factors including: triglycerides, cholesterol, LDL-C and HDL-C were measured. The results were analyzed using SPSS software and p Blood triglycerides, cholesterol and LDL-C decreased significantly but the level of HDL-C increased significantly in both groups. There was no significant difference between the two groups based on the other factors.
According to the results of the present study, pistacia powder consumption can decrease triglyceride, cholesterol, LDL and increase HDL levels, therefore the pistacia atlantica can be useful for individuals with mild hyperlipidemia.

Listeriosis is mainly caused by consuming unpasteurized dairy products, especially soft cheese which is contaminated with listeria monocytogenes in people with a damaged immune system. The purpose of this study was to evaluate the possibility of using natural preservatives to control the growth of Listeria monocytogenes in dairy products. In the present experimental study, plants (Thymus denaensis, Jaft and green hull Pistacia atlantica) were collected from the mountains of Kohgiloyeh & Boyerahmad province and their hydroaloholic extract were prepared. Antibacterial activities, MIC and MBC, were determined by disc diffusion and microwell dilution methods. The Ampicilin disk (10µg) was used as positive control in disc diffusion. The data were analyzed by the SPSS software using One-way ANOVA. The most anti-bacterial activities were found with hydroalcoholic extracts of Jaft and green hull Pistacia atlantica. Inhibition zone for the Jaft concentration was 32 mg/ml which was equal to the ampicillin disk. The minimum inhibitory concentration and minimum bactericidal concentration of Jaft extract were 125 and 250 μg/ml respectively. Based on the results of current study, hydroalcoholic extract of Jaft might be a suitable candidate to be used as a preservative in the food industry which is able to prevent the growth of Listeria monocytogenes.

Although the consumption of chemical drugs such as clofibrate and statins reduce serum lipids, they have undesirable side effects. So, at the present time the use of medicinal plants are preferred, because they are cheap, beneficially effective and of low undesirable side effects. The nuts of Anacardiace family have hypolipidemic effects on serum lipid profile by unknown mechanisms.Phosphatidate phosphohydrolase (PAP) is a key regulator enzyme in lipid metabolism. Therefore, the aim of this study is to determine effects of Pistacia khinjuk nut on PAP, serum lipid profile and liver content triglyceride in rats. Four groups of rats (n=6/group) were fed with normal diet (control) or normal diet plus 10% pistachio nut powder for 15 and 60 days. Then, PAP activity, triglyceride, total cholesterol, HDL-cholesterol, LDL- cholesterol, VLDL- cholesterol, and liver content triglyceride were measured. Feeding rats with pistachio nut for 15 days had significant elevated cholesterol in all lipoprotein fractions and reduced liver content triglyceride (P< 0.05). Although, PAP activity reduced approximately 11%, it was not significant in control group (P>0.05). On the other hand, rats fed with pistachio nut for 60 days had no significant differences with control group in all lipoprotein fractions (P>0.05), whereas the liver content triglyceride significantly decreased(P<0.05). In addition, PAP activity also decreased nearly 16% with respect to control group. The data shows that in pistachio nut, there is one or some substances able to elevate cholesterol metabolism. Hence, for understanding the effect of pistachio nut on lipid metabolism, it is necessary to prepare alcohol and water extraction of pistachio nut and examine them. On the other hand, in long time, no significant affection was seen. This may be due to the effect of essential fatty acids of nut, linoleic and linolenic, that can reduce serum lipids. Considering the fact that PAP is involved in the formation of fatty liver and also pistachio nut can result in reduction of liver content triglyceride by decreasing PAP activity in short and long courses, the pistachio nut can be used for the treatment of fatty liver through isolation and purification of effective components of it.