جستجوی مقالات مرتبط با کلیدواژه « گیاه جغجغه » در نشریات گروه « پزشکی »

Plants are useful natural sources of antioxidants for improving blood glucose control and preventing long-term complications of diabetes. The use of medicinal plants in the treatment of diabetes has shown significant impacts in reducing blood glucose in diabetic patients. The aim of the present study was to evaluate the effect of hydro – alcoholic extract of Prosopis farcta root on blood glucose, body weight and gene expression of pyruvate kinase (PK) in diabetic rats.
45 male wistar rats (average 250 gr) were randomly divided into three groups equally: healthy controls and diabetic controls and diabetic treated with the hydro-alcoholic extract of Prosopis farcta root. Type 1 diabetes was induced by i.p injection of streptozotocin (60 mg / kg BW). Rats were weighted at day 0, 15 and at the end of the study. Diabetic rats treated daily with 300 (mg/kg) for 30 days. Healthy control and diabetic control groups received distilled water during this time. Blood glucose and PK gene expression were measured on the 0, 15 and 30th days after feeding hydroalcoholic root extract of P. farcta. The data were analyzed by one-way ANOVA followed by LSD, and Dunnet T3 post-hoc test (P PK gene expression analysis showed its expression increased in treated rats compared to the control diabetes group on the 15th day of study but this declined on the 30th day (p According to achieved data of this study, it is suggested that a treatment of diabetic rats with hydro alcoholic root extract of Prosopis farcta could possibly reduce blood glucose by increasing the expression of PK.

Prosopis farcta plant is used traditionally in several parts of the country. Due to lack of scientific information on the cardiovascular effects of this plant, especially during ischemia - reperfusion and the importance of the issue, the present study was designed to investigate the effect of Prosopis farcta root extract on the isolated hearts of rats under ischemia-reperfusion condition. This experimental study included 58 rats which were divided into perfusion and ischemia-reperfusion groups. The hearts of the animals were isolated and then subjected to ischemia and reperfusion in langendorff setup, after baseline step. Parameters of cardiac function, including heart rate, left ventricular developed pressure (LVDP), rate pressure product (RPP) and coronary flow (CF) were assessed. The results showed that administration of aqueous extract of Prosopis farcta plant significantly reduced cardiac parameters including RPP (p=0.0242) and CF (p=0.0113) in perfusion group, and also exacerbated cardiac damage (RPP) induced by ischemia in the ischemic group compared to the control group (p= 0.0126). Considering the inhibitory effect of Prosopis farcta root extract on cardiac function, this plant may have useful effect on lowering blood pressure, but owing to its undesirable effects following myocardial ischemia, its administration is not recommended in these cases. The present results were not consistent with previous reports on nitric oxide dependent vasodilatory effect of this plant, and investigation of the compounds of this plant in different regions of the country is recommended in the future studies.

After axotomy or the compersion the nerve، the death of spinal cord nerves cell body occur. Compersion is one of the factors causing the degeneration of the spinal cord cell body. This degeneration is due to the reversed factors of the damaged area that have reached to cell body. Prosopis farcta is a member of leguminosae family and mimosaceae subfamily. The purpose of this study was to investigate the effect of ethanolic extract of pod prosopis farcta plant، on neuronal density of anterior horn following sciatic nerve compression in rat. This experimental study was performed on thirty male wistar rats with the age of about three months years and 300-350 gr weight. The animals were divided into five groups. A) control، B) compression، C) compression + treatment with 25 mg/kg ethanolic extract، D) compression + treatment with 50 mg/kg ethanolic extract and E: compression + treatment with 75 mg/kg ethanolic extract. After anesthetizing the rats، the muscle of thigh was splited and the sciatic nerve was kept under compersion، the muscle and skin were stitched subsequently. In the experimental groups the alchoholic extract of the prosopis farcta was injected to the rats with 25mg/kg، 50mg/kg، 75mg/kg dosage by the intrapritoneal way weekly. After 28 days of compresion، the rat، were put under the perfusion method and some samples were taken of their lumbar spinal cord and after tissue processes، 7 micron slide were provided of the samples serially. Slides were stained by toluidin blue، and some photos were taken and neuronal density of the alpha motoneurons alpha anterior horn of the spinal cord was calculated by the disector method. Data were analyzed using Minitab software، ANOVA and t- tests. The neuronal density in the compression group (628±29. 7) was decreased significantly in compare to the control group (1562±35. 3) (P<0. 05). The neuronal density in group C (1070±91)، increased significantly in compare to the compression group (p<0. 05). The neuronal density in group D (1117±62. 8) and group E (1669±86. 5) significantly increased in compare to the compression group (P<0. 05). This study showed that alchoholic extract of the prosopis farcta has a neuroprotective effect following sciatic nerve compression in rats.

Wound healing is a complex process which is divided into four overlapping phases: heamostasis، inflammation، proliferation، and remodeling. In diabetic patients، progression of healing takes longer and thus using new medication to accelerate it is required. It is expected that Prosopis farcta which has antibacterial، antidiabetic and antiinflammation effects will facilitate diabetic wound healing. Thus، the present study aimed at investigation the effect of aqueous extract of Prosopis farcta root on wound healing in diabetic rats. In this experimental study، 18 wistar male rats were randomly divided into 3 equal groups: normal control، Diabetic- control، and experimental group (diabetes treatment with root extract). Diabetes was induced through intraperitoneally injection of Streptozocin (STZ). Then، in all groups، in two lateral posterial parts 3 holes (4 mm in diameter) were punched. For 2days، 3 times on each، the experimental group was locally treated with root aqueous extract of Prosopis farcta. In the control groups normal saline was used in the same way. On the 4th، 8th and 10th day after punching samples were collected from the healing hole (which were now 6 mm in diameter). Histological observations revealed inflammatory cells، reepithelization، and neovascularization in the areas. Significant changes in proliferation of inflammatory cells (on the 10th day)، epithelium thickness (on the 4th and 8th day،)، more angiogenesis (on the 4th- 10th day) in the experimental wounds were compared with those in the diabetic control group (Respectively P<0. 001، P<0. 01). Considering the above findings، the extract of Prosopis farcta root، has effective roles on wound healing in diabetic rats، probably due to its anti- inflammatory، reepithelization، and neovascularization properties. However، more studies are needed in this respect.