جستجوی مقالات مرتبط با کلیدواژه « Blood platelet » در نشریات گروه « پزشکی »

Exercise can play a supportive role in the improvement of breast cancer by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory and anti-tumor cytokine that plays an important role in inhibiting tumor growth. This study was performed with aim to evaluate the effect of 12 weeks of combined exercise (aerobic_pilates) on the serum level of interleukin 10 and blood platelets in women with breast cancer.

This experimental study was performed on 30 women with breast cancer who had undergone at least 6 months of surgery and had received chemotherapy and were under treatment with medication in Azarbaijan Shahid Madani University in 2019. The subjects were divided into experimental and control groups. The experimental group performed 3 sessions of exercise each week (aerobic-pilates) for 12 weeks. During this time, the control group did not participate in any exercise or physical activity program. Blood samples were obtained before and 48 hours after exercise intervention to extract the variables. Data were analyzed by SPSS software (version 20) and independent and correlated t-test. P<0.05 was considered statistically significant.

The results of correlated t-test showed that the serum level of interleukin 10 (P =0.001) and the number of blood platelets (P =0.041) significantly increased in the experimental group after 12 weeks of combined training (aerobic-Pilates) compared to the pre-test, while this change was not significant in the control group (p> 0.05).

Performing combined exercises (aerobic_Pilates) by improving the status of interleukin 10 as an anti-inflammatory and anti-tumor cytokine can be useful in improving the health status of women with breast cancer. Therefore, designing and performing such exercises in this population can solve many problems of these loved ones.

Atherosclerosis is one of the leading causes of cardiovascular disease. Following endothelial damage and platelet aggregation in that area and the recruitment of monocytes and their conversion to macrophages, LDL gradually accumulates under the endothelial artery wall and gradually oxidized and convert to oxi-LDL. By swallowing it, the macrophages turn into foam cell and then atheroma formation. Medicinal plant extracts are used to treat diseases due to their low side effects. Cinnamon water extract modulates macrophage activation and lowers cellular cholesterol and is useful in the treatment of atherosclerosis. Therefore, in this study, the inhibitory effect of cinnamon in preventing the foam cell formation in platelets and monocytes co-culture was evaluated.

The cellular toxicity of cinnamon cassia water extract was assessed by the MTT test on the U937 (monocyte) cell line and the best dose was selected. The formation of foam cells was measured by Oil Red O staining and the expression of cholesterol receptor genes in macrophages using Real time PCR.

The data showed that the formation of foam cell when treating macrophages and platelets with cinnamon water extract  compared to control, had a significant reduction. The expression of LXRα, CD36, ABCA1, and PPARY genes, as the output receptor, input, and nucleus of cholesterol in macrophages, increased significantly compared to control in samples treated with cinnamon(P<0.05).

Cinnamon water extract reduces the formation of foam cells and can be recommended in the treatment of atherosclerosis.