جستجوی مقالات مرتبط با کلیدواژه « Cardiac ischemia » در نشریات گروه « پزشکی »

 Curcumin has potential anti-inflammatory effects. The aim of this study was to investigate the protective effect of curcumin against cardiac ischemia -reperfusion injury in rats fed a high-fat diet.

 In this experimental study, male Wistar rats were divided into four groups: control (C), high-fat diet (H), curcumin 100 (HyperC100, 100 mg/kg) and curcumin 200 (HyperC200), with the last two groups receiving oral curcumin daily for 3 weeks.
The rats were fed a high-fat diet for 7 weeks to induce obesity. After anesthesia, hearts were removed and placed on the Langendorff perfusion system andbegan beating. After 20 minutes of stabilization, 35 minutes of ischemia and 60 minutes of nutrient fluid reflux were performed. During this interval, ventricular (LV) functional indices including LVSP, LVDP, LVEDP and +dp/dt were recorded. The relative size of the infarction was measured by using 2,3,5-triphenyltetrazolium chloride staining.

 Hyperlipidemia caused dysfunction with changes in ventricular parameters, but curcumin could to improve some LV contractile parameters such as systolic pressure and increase diastolic pressure (P≤0.05). Curcumin could not significantly reduce the infarct size.

 Curcumin may have an cardio protection effects against ischemia/reperfusion injury in normal and hyperlipidemic rats.

NF-κB factor is activated by ischemic damage and reperfusion and has a crucial role in transcription of several genes. Applying DNAzyme is one of the novel therapeutic means. Niosome is a new drug delivery system that is controllable ae used targeted. Applying DNAzyme-containing nanoniosome to diminish the expression of NF-κB protein after cardiac ischemia.

In the current study, twenty-five male rats were assigned into 5 groups: 1- Control group, 2- Ischemic induced group, 3- Post ischemic DNAzyme receiving group, 4- Post ischemic DNAzyme-bearing nanoniosome receiving group, and 5- Post ischemic nanoniosome receiving group. After 72 hours, western blotting was performed on rats’ hearts to assess expression of NF-κB protein in treated groups.

post ischemic treatment with DNAzyme-bearing nanoniosome led to considerably decrease of NF-κB expression compared to ischemic rats (P<0.05).

Results demonstrated the efficiency of DNAzyme-containing nanoniosome on NF-κB protein after cardiac ischemia. Therefore it is propounded as a curative method for cardiac ischemia

The risk of heart ischemia after radiotherapy has not been determined precisely, and since myocardial ischemia jeopardizes the results of breast cancer treatment, we decided to increase the risk of heart ischemia after breast radiotherapy and the factors affecting in women candidates for general anesthesia for surgery.Materilas and

In this cross-sectional descriptive study, 209 patients referred to the operating room of Imam Reza Hospital in Tabriz with a history of radiotherapy by census method in the one year leading to September 2017 were included in the study. Demographic and Rose profile checklist (diagnosis of myocardial ischemia) was used for research purposes and the data were analyzed by logistic regression and Wilcoxon tests after entering SPSS21 software. P value less than 0.05 was considered significant.

Standard deviation; mean score of cardiac ischemia diagnostic index was 04.88 ± 0.93, of which 78 patients (37.33%) scored higher than 5 and 131 patients (62.67%) scored less than 5; seven potential ischemic related factors Patients at high risk for radiotherapy were identified as including age (OR=0.35, p=0.009), BMI (OR=0.38, p=0.007), and chemotherapy (OR=0.29, p = 0.005), tumor size (OR=0.45, p=0.005), tumor location (OR=0.09, p=0.02), tumor involvement side (OR=0.33, p=0.003)Number of radiotherapy sessions (OR=0.60, p=0.001).

Radiotherapy for the treatment of breast cancer as a risk factor for cardiac ischemia in women is a candidate for general anesthesia for surgery, which is exacerbated by factors such as age, body mass index, chemotherapy, tumor size and location, side involved and the number of radiotherapy sessions.