جستجوی مقالات مرتبط با کلیدواژه « Clinical Trial Study » در نشریات گروه « پزشکی »
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Background
Due to its invasiveness and length, bimaxillary orthognathic surgery causes highly excruciating pain in the oropharyngeal area for the patient. There are several ways to reduce this pain, including prescribing painkillers and anti-inflammatory drugs. The aim of this study was to evaluate the effect of photobiomodulation by a 940-nm laser on reducing pain in the oropharyngeal area after bimaxillary orthognathic surgery.
MethodsThis randomized clinical trial study was performed on 40 patients aged 17-40 years who were candidates for bimaxillary orthognathic surgery referred to the Department of Oral and Maxillofacial Surgery of Besat hospital in 2021. All patients in the intervention group underwent the photobiomodulation of the oropharyngeal area with a 940-nm diode laser immediately after the end of bimaxillary orthognathic surgery. Sore throat, jaw pain, pain when swallowing, and stridor were recorded in the first to fifth days after surgery. Finally, changes in the mean score of indices were compared within and between the two groups using repeated measure analysis of variance.
ResultsThe mean age of patients in the intervention and control groups was 22.4±4.38 and 25.15±5.48 years, respectively (P=0.09). The pain score in the four areas studied in both intervention and control groups had a decreasing trend over time, which was statistically significant (P<0.001). In addition, the difference in the trend between the two groups was statistically significant so that in the intervention group, the decreasing trend was more severe (P<0.05). Eventually, a significant interaction was observed between the type of intervention and time in all four areas (P<0.05).
ConclusionsThe results showed that the use of a 940-nm diode laser led to a significant reduction in all four areas of sore throat, pain when swallowing, and stridor after bimaxillary orthognathic surgery.
Keywords: Pain, Bimaxillary orthognathic surgery, Photobiomodulation, Clinical trial study} -
Background :
Paracetamol and Pethidine are two prevailing analgesics prescribed for postoperative orthopedic patients, each having different side effects and impacts on fracture healing. The present study was conducted to compare the impacts of Paracetamol and Pethidine on postoperative pain relief of children with bone fractures.
Materials and MethodsFifty children with orthopedic bone fracture surgery candidates were selected in a double-blinded clinical trial study. A random number table was utilized to classify children into two groups of Paracetamol or pethidine treatment. First, the pain intensity of each group was checked using the Visual Analog Scale (VAS). Six hours after the surgery, the first group received Pethidine (1mg/kg of body weight), and the second group received Paracetamol (1gr). Moreover, the VAS scales were checked for both groups 6, 12, and 24 hours later. Afterward, the pain intensity of both groups was assessed according to the VAS scale.
ResultsIndependent t-test results revealed a significant difference between the pain intensity of paracetamol (44.24 ± 6.44), and Pethidine (52.68 ± 10.47) groups 6 hours after the surgery (p=0.03). Moreover, there was also a significant statistical difference between the pain intensity of two groups 12 and 24 hours after the surgery.
Conclusion:
Given the effectiveness of Paracetamol and Pethidine on postoperative pain, both medications can be used for children with bone fractures.
Keywords: Children, Pethidine, Paracetamol, Clinical Trial Study} -
مقدمهاضطراب آشکار ازجمله مشکلات روان شناختی شایع در بین بیماران سرطانی است. این مطالعه با هدف بررسی تاثیر تجسم هدایت شده بر اضطراب آشکار بیماران مبتلا به سرطان انجام شد.مواد و روش هاپژوهش حاضر یک کارآزمایی بالینی تصادفی است که در بخش سرطان بیمارستان شهید بهشتی کاشان در سال 1397 انجام شد. آزمودنی ها شامل 70 بیمار سرطانی بود. نمونه ها به طور تصادفی انتخاب و به دو گروه 35 نفری مداخله و کنترل تقسیم شدند. از نمونه ها رضایت آگاهانه کتبی گرفته شد، آزمودنی ها پرسش نامه های دموگرافیک و اضطراب آشکار اشپیل برگر را تکمیل کردند. گروه مداخله، 8 جلسه، هر هفته دو بار به مدت چهار هفته تحت آموزش تجسم هدایت شده قرار گرفتند و مجددا پرسش نامه اضطراب آشکار را تکمیل کردند. داده ها با آزمون های مجذور خی دو، تی تست و تحلیل کوواریانس آنووا در نسخه 16 نرم افزار SPSS تجزیه وتحلیل شد.یافته هانتایج آزمون تحلیل کوواریانس آنووا نشان داد بین گروه ها در پس آزمون در مقایسه با پیش آزمون تفاوت معنی دار وجود داشت. میانگین نمرات گروه تجسم هدایت شده در متغیر اضطراب آشکار در پس آزمون نسبت به گروه کنترل به ترتیب (6/82 ± 54/ 17) و (6/45 ± 41/67) بود که نشان دهنده کاهش معنی دار آن است (0/001p=).نتیجه گیریتجسم هدایت شده می تواند به طور معناداری علائم اضطراب را در بیماران سرطانی کاهش دهد لذا به نظر می رسد استفاده از روش های طب مکمل، جایگزین مناسبی برای پیشگیری از عوارض داروهای شیمایی باشد.کلید واژگان: اضطراب آشکار, تجسم هدایت شده, سرطان, درمان مکمل, کارآزمایی بالینی}Complementary Medicine Journal of faculty of Nursing & Midwifery, Volume:9 Issue: 2, 2019, PP 3718 -3729IntroductionState anxiety is one of the common psychological problems among cancer patients. The aim of this study was to determine the effect of guided imagery on the state anxiety of cancer patients.MethodsThis randomized, clinical trial study was conducted on 70 cancer patients who were randomly selected from the patients in the cancer ward of Shahid Beheshti Hospital in Kashan in 2019. The participants were assigned to two 35-member groups of intervention and control, filling demographic questionnaires and The State-Trait Anxiety Inventory (STAI). Then, the intervention group received 8 sessions of guided imagery, twice a week for four weeks and again filled out the anxiety inventory. The data were analyzed through SPSS 16 using Chi-square, t-test and ANOVA. and ANCOVA.ResultsThe results of ANCOVA test showed that there is a significant difference between the groups in the post-test compared to the pre-test. The mean scores of the imagery group in the state anxiety variables significantly decreased in the post-test (54.17±6.82) compared to those in the control group (41.67±6.45). (p<0.001).ConclusionThe results of this study showed that guided imagery can significantly reduce the anxiety symptoms in cancer patients, which can be useful in caring cancer patients while decreasing treatment cost.Keywords: Anxiety, Guided Imaging, Cancer, Complementary treatment, clinical trial study}
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Background And ObjectivesOptimal surgical management of the neonate with imperforate anus (IA) depends on determining accurate location of muscle complex, pouch of rectum and urethral fistula. The aim of this study was to investigate a novel minimally invasive technique of anorectoplasty assisted by intraoperative sonography pull-through for repair of anorectal malformation and rectourinary fistula.
Patients andMethodsEight male patients with imperforate anus aged under 48 h had undergone colostomy. Any associated anomalies were evaluated in cases. After 5-8 weeks, neonates were prepared for anoplasty. After catheterization, sonography of perinea was carried out. Patients were placed in lithotomy position. The accurate position of each required point was determined by this procedure.ResultsIn all cases, the pouch of rectum to skin distance was in range 1.5-1.8 mm and entrance distance of wire to fistula was maximally 6 mm, just in one patient this value was 7 mm. Anomalies associated with some patients were Down Syndrome, cardiac anomalies, kidney disease .6 out of 8 patients removed urinary catheter after two days and discharged home. Colostomy of all patients was closed after sonography of prinea. After one week and one month follow- up, all patients had an acceptable fecal frequency about 3- 5 times a day.ConclusionIntra-operative sonography is an applicable procedure to determine correct location of muscle complex, pouch of rectum and uretral fistula to treat IA patients non- invasively. Another interesting point of this study is the ability of non invasive surgery and novel procedure with perfect result.Keywords: Anorectal malformations, Children, Clinical Trial Study, sonography} -
BackgroundHydatidosis is a conventional health public problem in most parts of the world. Safe treatment of patients with hydatidosis has been a topic of debate for a long time. Surgical treatment always was associated with high morbidity and mortality. Medical treatment is also controversial. In this study, alternative procedure named Percutaneous, Aspiration and hypertonic Saline Instillation (PAHSI) was applied to treat patients with hydatidosis.
Materials and MethodsIn this single-blind clinical trial, thirty-eight patients, ranging in age between 6 months and 16 years, with 81 hepatic hydatid cysts underwent PAHSI treatment. The consecutive steps including sonographic guidance, aspiration of cyst content and injection of 15% saline hypertonic were carried out in this method. Patients with multiple cysts also were treated by this procedure.
ResultsParticipants were 18 boys (47.3%) and 20 girls (52.6%) with mean age of 8.08 3.92 years. Almost half of the patients had single cyst (52.63%). During 2- year follow- up, no recurrences were observed; therefore, re-hospitalization and possible complications reduced considerably. Furthermore, this method was applicable to cure multiple cysts.
Conclusion In PAHSI strategy, it seems that the complications of surgery (laparotomy and anesthesia) decreased since no complications observed after procedure, and cosmetic results in future are much better due to avoidance of incision.Keywords: Children, Clinical Trial Study, Hydatidosis, Iran, Treatment} -
International Journal of Musculoskeletal Pain prevention, Volume:1 Issue: 3, Summer 2016, PP 93 -100Mini abstract: This study is an extended follow up of the original trial study (NCT00600197) that has been published in the clinical journal of pain. This trial aimed to explore if the proposed multidisciplinary program could improve quality of life and disability of the patients suffering from chronic low back up to 36 months.
Methods and Material: In this Clinical Randomized trial seventy percent (139 of 197) of the participants who had taken part in the original study including 66 patients in intervention group and 73 patients in control group were followed up to 36 months after intervention. The intervention group continued receiving monthly motivational consultation and booster classes plus oral medication but the other group received just medication. Data on measures of Short Form 36 (SF- 36), Quebec Disability Scale (QDS) and Ronald Morris Disability (RDQ) were collected at 3-,6- 12-, 18- 24-, 30-. and 36 - month follow ups and analyzed through RMANOVA.ResultsThe 2 groups were comparable regarding all baseline characteristics (P>0.05), except for education level that was better in intervention group (P = 0.01). Two groups were improved regarding all studied variables over time up to 36 month (PConclusionsThe proposed multidisciplinary program could improve quality of life and disability up to 36 months in chronic low back pain patients.
Key - Words: This study revealed the designed multidisciplinary program compared with medication group could reduce back pain up to 36-months among patients suffering from Chronic Low Back Pain.
This study showed the multidisciplinary program compared with medication group could reduce disability up to 36-months among patients suffering from Chronic Low Back Pain.
In total, the quality of life of patients who took part in multidisciplinary program would be improved better than medication group over 36- month follow up.Keywords: Low Back Pain, ultidisciplinary Group, based Rehabilitation, Clinical trial study}
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