جستجوی مقالات مرتبط با کلیدواژه « Continues Exercise » در نشریات گروه « پزشکی »

Expression of FoxO transcription factors whould increase during certain forms of atrophy. In a dephosphorylated state, FoxOs participate in ubiquitin-mediated proteasomal degradation through the transcriptional activation of E3-ubiquitin ligases such as MAFbx/atrogin-1. Therefore, the study aimed to determine the effect of combination of continuous exercise and resveratrol supplementation on foxo-1 and Atrogin-1 gene expression in the left ventricular tissue of male Wistar rats.

In this study, 25 male Wistar rats with 180-250 g weight were randomly classified into 5 groups, including healthy control (n=5), diabetic control (n=5), diabetic resveratrol (n=5), diabetic-continuous exercise (n=5), and resveratrol+ continuous exercise+ diabetes (n=5). After inducing diabetes by intraperitoneal injection of streptozotocin, animals in expremental groups were carried out an 8-week exercise program on a treadmill with 60-75% Vo2max. One-way ANOVA and Tukey test with statistical level (P<0.05) was used to compare the differences between groups.

The results showed that gene expression of Atrodin-1 were significantly markedly in the ARDM group compared to the DM group (P= 0.02) but the gene expression of foxo-1 only was significantly changed (P= 0.001) in ARDM group to compared with the other groups (P>0.05).

It seems that the Foxo1 gene expression fluctuations along with the significant decrease in the expression of the atherogen-1 gene can be improving the diabetic heart as a non-pharmacological method.

Introdution: The research has been indicated that reactive oxygen species induced the apoptosis of cardiomyocytes. However, this mechanism has been unclear. The aim of this study was to investigate the effects of concurrent training on some of the heart apoptosis variables
(BAX,BCL-2) following by the injection of different H2O2 dose in Wistar rat males.

50 male rats were randomly assigned to 5 groups with 10 rats in which group. Groups included: group (1): control group (C), group (2, 3): injection of 1 and 2ml H2O2, group (4,5): exercise and injection of 1and 2 ml H2O2. Exercise groups have been run on treadmill for four days during 8 weeks at moderate intensity. 24 hr after the last exercise and in anesthetic state all rats have been knockouted to determine bax and bcl2 proteins ratio. For measuring the BAX and BCL-2 proteins were used by ELISA technic and total protein were determined by brad ford technic. Data were analyzed by SPSS 17, one ways ANOVA was used to analysis of data at the level of p≤0/05.

The results have been indicated that after two month continues training no significant difference in BAX, BCL-2 proteins and BAX/BCL2 ratio in exercise and H2O2 groups in compared by control groups.

based on the result of this study if the 8-week continues training has been followed by H2O2 injection with both of one and two ml H2O2 concentration, it may not have induced apoptosis cardio myocyte in rats. And it may adjusted the synthesis and degradation myocardial