جستجوی مقالات مرتبط با کلیدواژه « Developmental » در نشریات گروه « پزشکی »

Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in neurons and their supportive cells in developing the vertebrate Central Nervous System (CNS). 

This study investigates the HDAC11 potential role in early chicken CNS development by studying its mRNA expression profile which may have unique means in studying human subjects. 

Chicken HDAC11 RNAs were reverse transcribed to cDNAs, and the amount of chHDAC11 transcripts was measured by ΔCT mean calculation using the real-time quantitative PCR method. One-way ANOVA and Duncan’s analysis (SigmaStat software version 4.0) were used to test the statistical significance of the results. The levels of significance were set at P≤0.05. Quantitative data are presented as Mean±SD.

The amount of HDAC11 mRNAs gradually increases, at least 2-3 times, from as early as day 14 (E14/HH40) of prenatal cortex formation to day P0 (E20=HH45) and continue to increase to day 40 in both cortical and hippocampal regions of the postnatal chicken brain during development (*P≤0.05). HDAC11 mRNA is not only expressed in the postnatal cortex and hippocampi regions but also—for the first time—in the developing brain during the prenatal period.

Our results show a possibly important role for the latest found HDAC11 conserved gene in the development of vertebrates’ embryonic brain, which in turn may have a significant impact on understanding human brain development.

 Improvement of the quality of life of people with developmental disorders and their full integration within society requires comprehensive mental, intellectual, and physical rehabilitation. To achieve a favorable outcome, rehabilitation should be delivered in a continuous manner and with small attrition. Research in this area is scarce.

 The current study aimed to determine the incidence of dropout from rehabilitation and its associated factors in children with developmental disorders.

 In this prospective study, we recruited 225 children with developmental disorders and their parent (s) seeking rehabilitation services for the first time. They attended different centers in all regions of Tehran during 2016 - 2017. We completed a checklist using semi-structured interviews. The follow-up was performed every three months for at least six months to record the dropout from rehabilitation and the associated factors. Data analysis included the chi-square test and logistic regression.

 The dropout rate was found to be 10.9% within three months and reached a total of 19.3% in six months. It was significantly associated with the following factors after eliminating confounding effects: (1) poor family satisfaction with the centers in three-month analysis (OR = 10.76; CI: 2.764 - 41.906, P = 0.001) and after six months (OR = 4.51; CI: 1.30 - 15.67, P < 0.02); (2) the type of service sectors (public and charity vs. private) (OR = 7.12; CI: 2.12 - 23.93, P = 0.002); (3) moderate severity of the developmental disorder in three-month analysis (OR = 4.55; CI: 1.24 - 16.78, P < 0.03); (4) child's perceived “lack of cooperation” in attending rehabilitation sessions in six months (OR = 6.79; CI: 1.42 - 32.53, P < 0.02); and (5) the type of developmental disability (specific learning disorder vs. others) in six months (OR = 6.68; CI: 2.85 - 15.65, P < 0.001). In the open questions, the high cost of services was stated as the most important reason for dropout.

 Our findings indicate that dropout was associated with family dissatisfaction with the low quality of services, mainly in the public and charity centers. Children with disabilities of moderate severity were most likely to drop out from rehabilitation. Specific learning disorders seem to be the most challenging type of disability that leads to the highest dropout rates. The findings provide opportunities for further research in this area and to gain more information to render rehabilitation services more efficiently.

Early diagnosis is considered as a priority for prevention and treatment of asphyxia-related complications. The main aim of the present study was to evaluate the prognostic value of interleukin-6 (IL-6) and hypoxic ischemic encephalopathy grade in prediction mortality and developmental status of neonates affected by prenatal asphyxia.

The cohort study was conducted on 38 term asphyxiated infants at Ghaem hospital, Mashhad, Iran, during 2013-2017. The HIE grade and serum IL-6 levels were determined at the time of birth. The developmental status was determined using the Denver II test at the end of two-year follow-up.

HIE grade 3 resulted in 83% mortality rate and developmental delay in all the survivors. The average IL-6 level was 2.7 ng/ml in the control group (not affected HIE) which increased up to 29, 175 and 136 ng/ml in those with HIE grades 1, 2 and 3, respectively. Roc curve analysis revealed the cut-off levels 24 pg/ml to predict the developmental delay with sensitivity and specificity of 96 and 92%, respectively.

The IL-6 level and HIE grade are the potential prognostic biomarkers for determination of mortality and morbidity rate in the asphyxiated neonates

The orthokeratinized odontogenic cyst (OOC) is an uncommon developmental cyst that occurs between the second to fifth decades, more commonly in males. It is a solitary lesion that mostly occurs in the mandible rather than the maxilla. Histologic features include a thin, uniform epithelial lining with orthokeratinization and a prominent granular layer below a non-corrugated onion-skin-like surface.
A 40-year-old man presented with pain and swelling in the left mandibular canine molar area. The panoramic radiograph revealed a well-defined radiolucency extending from the left mandibular canine to the left mandibular molar, with scalloped projections between the teeth roots. Microscopic examination showed a cystic lesion lined by an orthokeratinized stratified squamous epithelium, and a prominent granular layer beneath the cornified layer was seen. The features were those of an OCC.
From the demographic and radiographic perspectives, the features of OOCs can be similar, but more variation can be found on routine histopathological analyses.

The glandular odontogenic cyst (GOC) is a rare developmental cyst that was described in 1988 by Gardner, et al. This lesion demonstrates non-specific clinical course and radiological findings. Hence, often confused with other lesions, but specific histopathlogical features help in establishing its correct diagnosis. This article presents a rare case of a maxillary glandular odontogenic cyst in a 70-year-old female patient.

Developmental dysplasia of the hip (DDH) or congenital hip dysplasia (CDH) is the most prevalent developmental childhood hip disorder. It includes a wide spectrum of hip abnormalities ranging from dysplasia to subluxation and complete dislocation of the hip joint. The natural history of neglected DDH in adults is highly variable. The mean age of onset of symptoms is 34.5 years for dysplastic DDH, 32.5 years for low dislocation, 31.2 years for high dislocation with a false acetabulum, and 46.4 years for high dislocation without a false acetabulum. Thorough understanding of the bony and soft tissue deformities induced by dysplasia is crucial for the success of total hip arthroplasty. It is important to evaluate the existing acetabular deformity three-dimensionally, and customize the correction in accordance with the quantity and location of ace tabular deficiencies. Acetabular reconstruction in patients with DDH is hallenging. Interpretation of published data is difficult and should be done with caution because most series include patients with different types of hip disease. In general, the complication rate associated with THA is higher in patients with hip dysplasia than it is in patients with osteoarthritis. Overall, clinical and functional outcomes following THA in patients hip dysplasia (DDH) differ from those treated for primary hip osteoarthritis, possibly due to the lower age and level of activity. Although function scores decline with age, the scores for pain and range of motion presented with a statistically significant improvement in the long-term.