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جستجوی مقالات مرتبط با کلیدواژه « Emulsion » در نشریات گروه « پزشکی »

  • Atefeh Norabi, Hesam Mashhadi, Mahnaz Tabibiazar*, Hamed Hamishehkar
    Background

    Emulsion-based formulations have gained attention in food and pharmaceutical products due to their unique properties. However, their use in food product formulation faces problems because of phase separation and fat oxidation, which seriously reduces the quality of the product. Therefore, finding ways to increase the physical and oxidative stability of emulsions is valuable. This work aimed to assess of physicochemical properties of sodium caseinate (SC)-tannic acid (TA) complex treated with heating and ultrasonication as well as their efficiency in physical and oxidative stability of high internal phase Pickering emulsion (HIPPEs) as antioxidant colloidal particles.

    Methods

    SC 1% (w/v) was mixed with a different concentration of TA (0.1, 0.3, 0.5, 0.7, 1% w/v) and the pH of solutions was adjusted to 9. The unheated, heat-treated, and ultrasonicated SC-TA complexes were analyzed to elucidate possible interaction using FTIR, fluorescence spectroscopy, and DSC. Finally, HIPPEs were prepared by mixing the prepared samples and soybean oil at a volume ratio of 25:75 v/v respectively. The microstructure of the most stable HIPPEs was assessed using SEM.

    Results

    Based on the FTIR results the covalent bond in heat-treated SC-TA was formed via the Maillard reaction. In addition, the reduction of free amino groups confirms Schiff base formation. All treated SC-TA samples showed a superior ability to stabilize emulsion in comparison with native SC when used as an aqueous phase of HIPPEs. The long-term physical was observed in heat-treated SC-TA HIPPEs for over two months. In PEs stabilized by SC-TA complex nanoparticles, primary and secondary oxidation product levels were significantly lower than in SC alone.

    Conclusion

    The fabricating antioxidant emulsions using heat-treated SC-TA are a good guarantee for the physical and oxidative stability of food formulations due to TA's intrinsic antioxidant properties and the protective role of SC-TA colloidal particles against coalescence.

    Keywords: Colloidal particles, Emulsion, Oxidative stability, Physical stability}
  • علی فرخی، مهدی صابری، زهرا بهاری، زهره جنگروی، مریم ایمان*
    زمینه و هدف
    درد مزمن نوروپاتیک یکی از مشکلات شایع و ناتوان کننده جوامع بشری است و در مراقبت های بهداشتی چالش بر انگیز است. گیاه سنبل الطیب (Valeriana officinalis) از گذشته تا کنون، به دلیل اثرات آنتی اکسیدانی و مکانیسم های متعددش، در درمان درد و اضطراب کاربرد داشته است. همچنین شکل دارویی امولسیون نیز در افزایش فراهمی زیستی و جذب فرآورده های گیاهی مورد مطالعه است. مطالعه حاضر با هدف تعیین اثرات ضد دردی و ضد اضطرابی امولسیون خوراکی عصاره و مقایسه آن با اثرات عصاره در موش صحرایی بالغ نر صورت گرفت.
    روش ها
    ابتدا امولسیون خوراکی عصاره به کمک مطالعات مشابه و نرم افزار Design Expert فرموله شد و بهترین فرمولاسیون انتخاب گردید. سپس درد نوروپاتیک به کمک مدل جراحی نوروپاتی ضایعه انسدادی مزمن عصب سیاتیک  (CCI)در حیوان القا گشت. عصاره و امولسیون به صورت خوراکی (گاواژ معدی) به مدت 30 روز به حیوانات داده شدند، پس از آن تست های رفتاری استن، جهت بررسی آلودینیای حرارتی، و ماز مرتفع ب علاوه ای شکل (EPM)، جهت بررسی رفتارهای اضطرابی القایی، در یک روز قبل از القای نوروپاتی و نیز در روز های 2، 4، 6، 10، 14، 21، 30 بعد از نوروپاتی بررسی شدند، همچنین در انتها سنجش اثرات گاواژ امولسیون خوراکی عصاره و عصاره  بر پراکسیداسیون لیپید مالون دی آلدیید (MDA) در بافت مغز مورد بررسی و مقایسه قرارگرفت.
    یافته ها
    تجویز جداگانه عصاره و امولسیون سنبل الطیب سبب کاهش آلوداینیای سرد در تمام روزهای پس از جراحی CCI در مقایسه با گروه نوروپاتی شدند (0/05>P). علاوه بر این، جراحی CCI سبب ایجاد اضطراب در موش ها شد. که تجویز امولسیون سنبل الطیب و عصاره آن توانست به طور معنی داری سبب کاهش اضطراب در تست رفتاری ماز مرتفع بعلاوه ای شکل شود. با این تفاوت که با تجویز امولسیون عصاره این روند کاهشی زودتر شروع شد (0/001>P). همچنین تجویز عصاره و امولسیون به طور معنی داری میزان مالون دی آلدیید را در بافت مغز را در موش های نوروپاتیک در مقایسه با گروه نوروپاتی کاهش دادند (0/001>P)، با این تفاوت که امولسیون عصاره باعث کاهش بیشتر میزان مالون دی آلدیید، نسبت به عصاره گردید.
    نتیجه گیری
    عصاره و امولسیون سنبل الطیب دارای اثرات ضد دردی و ضد اضطرابی هستند. علاوه بر این، تجویز امولسیون سنبل الطیب در موش های نوروپاتیک به طور معنی داری اثرات ضد اضطرابی و ضد دردی بیشتری در مقایسه با تجویز عصاره  سنبل الطیب، دارد.
    کلید واژگان: درد نوروپاتیک, امولسیون, آلودینیا, سنبل الطیب, گلوتاتیون}
    Ali Farokhi, Mahdi Saberi, Zahra Bahari, Zohreh Jangravi, Maryam Iman *
    Background and Aim
    Chronic neuropathic pain is one of the common and debilitating problems of human societies and is a challenge in health care Valerian officinalis has been used in the treatment of pain and anxiety due to its antioxidant effects and multiple mechanisms. Also, the medicinal form of emulsion is studied to increase the bioavailability and absorption of herbal products. The present study was conducted to determine the analgesic and anti-anxiety effects of the oral emulsion of the extract and compare it with the effects of the extract in adult male rats.
    Methods
    First, the oral emulsion of the extract was formulated with the help of similar studies and Design Expert software, and the best formulation was selected. Then, neuropathic pain was induced in the animals with the help of a sciatic nerve chronic obstructive lesion (CCI) neuropathy surgical model. The extract and emulsion were given orally (gastric gavage) to the animals for 30 days, after which behavioral tests were performed, to investigate thermal allodynia, and elevated plus maze (EPM), to investigate induced anxiety behaviors, one day before Induction of neuropathy and on days 2, 4, 6, 10, 14, 21, 30 after neuropathy were investigated, and at the end, the effects of oral emulsion gavage of extract and extract on lipid peroxidation of malondialdehyde (MDA) in brain tissue were investigated and compared.
    Results
    Separate administration of valerian extract and emulsion reduced cold allodynia in all days after CCI surgery compared to the neuropathy group (P<0.05). In addition, CCI surgery caused anxiety in rats. Administration of valerian emulsion and its extract were able to significantly reduce anxiety in the behavioral test of the plus-shaped elevated maze. The difference is that this reduction process started earlier with the administration of the extract emulsion (P<0.001). Also, the administration of the extract and emulsion significantly reduced the amount of malondialdehyde in the brain tissue in neuropathic rats compared to the neuropathy group (P<0.001), with the difference that the emulsion of the extract caused a greater decrease in the amount of malondialdehyde compared to the extract.
    Conclusion
    Valerian extract and emulsion have analgesic and anti-anxiety effects. In addition, the administration of valerian emulsion in neuropathic rats has significantly more anti-anxiety and analgesic effects compared to the administration of valerian extract.
    Keywords: Neuropathic Pain, Emulsion, Allodynia, Valeriana Officinalis, Glutathione}
  • Amir Hosseinvand*, Elena G. Kovaleva, Adeleh Sorkhinejad
    Background and Objectives

    In this study, think over to collected and classification of food science engineering comprehensive datas about each experiment with expanded results. Moreover, in most of discussion added extra reasons to each phenomenon. The aim of the present study was assesse of E1442 with xantan gum as fat replacers of carbohydrate base on physicochemical and sensory evaluation of low-fat mayonnaise.

    Materials and Methods

    Four treatments were designed with 25, 50 and 75% replacements of the control sample with traditional mayonnaise (65% oil content).

    Results

    On emulsion stability of the samples, results were significant (P ≤0.05) for the storage time. In addition, physicochemical results showed that low fat mayonnaise prepared with present fat replacers of carbohydrate base (E1442 and xanthan gum) access to highest amounts in ash and moisture and also lowest in fat content and calorie. pH and acidification were in ranges of (3.70-3.73) and (1.12-1.13) respectively. Low fat mayonnaise samples were higher than apparent viscosity than that control sample was. Sensory evaluation results showed that fat with 0.25% concentration were at highest in overall acceptability and intent to purchase which are the most important factors in marketing.

    Conclusions

    In general, result demonstrated that low-fat mayonnaise prepared with 25% of E1442 with xantan gum was an appropriate  treatment with highest scores in most of  the experiments.

    Keywords: Mayonnaise, Fat replacer, Emulsion, Xantan Gum, E1442}
  • شهرزاد اکبری، رامین اصغریان*
    سابقه و هدف

    هدف این مطالعه ایجاد یک امولژل پوستی پایدار از داروی موپیروسین بود.

    روش بررسی

    این مطالعه در گروه فارماسیوتیکس دانشگاه علوم دارویی تهران از آبان 1399 تا شهریور 1400 انجام شد. در ابتدا مطالعات پیش فرمولاسیون روی پودر موپیروسین صورت گرفت و نمودار استاندارد رسم شد. در ادامه پایه های امولژل بدون دارو ساخته شد، پایداری آنها بررسی شد و فرمولاسیون برتر انتخاب شد. در ادامه فرمولاسیون امولژل حاوی دارو تهیه شده و مطالعات بیشتری از قبیل تعیین مقدار ماده موثره، آزاد سازی دارو در محیط برون تن و تعیین هاله عدم رشد صورت گرفت. 

    یافته ها

    امولژل حاوی کربومر 940، پارافین مایع به میزان 5%، تویین 20 به میزان 4/0% و اسپن 20 به میزان 1/1% به عنوان فرمولاسیون برتر انتخاب شد. نتایج آزمون های پایداری، پخش پذیری و... مناسب بود. مقدار ماده موثره در فرمولاسیون ها بین 90 تا 110 درصد بود. در مدت 8 ساعت دارو تقریبا به میزان 85% آزاد شد. از نظر ریولوژی، فرمولاسیون از رفتار غیر نیوتونی تبعیت می کرد.  همچنین رفتار پلاستیک و تیکسوتروپ نشان داد. مشاهده هاله عدم رشد در اطراف فرمولاسیون های حاوی دارو نشان داد که داروی موپیروسین از پایه امولژل آزاد شده و از رشد باکتری های استافیلوکوکوس اوریوس جلوگیری می کند.

    نتیجه گیری

    می توان یک فرمولاسیون امولژل پایدار از داروی موپیروسین تهیه کرد. پیشنهاد می شود که مطالعات پایداری تسریع شده و ادواری و اسکیل آپ فرمولاسیون جهت تولید صنعتی صورت گیرد.

    کلید واژگان: امولژل, موضعی, پوستی, موپیروسین}
    Shahrzad Akbari, Ramin Asgharian*
    Background

    The aim of this study was to develop a stable skin emulsifier from mupirocin.

    Materials and methods

    This study was performed in the Department of Pharmacy, Tehran University of Pharmaceutical Sciences from November 2016 to September 2015. Initially, preformulation studies were performed on mupirocin powder and a standard diagram was drawn. Next, the bases of the drug-free emulsifiers were made, their stability was investigated and the superior formulation was selected. The next step was the formulation of the emulsion containing the drug. Further studies such as determining the amount of active ingredient, releasing the drug in vitro and determining the aura of stunting were performed.

    Results

    Emulsifier containing 940 carbomer, 5% liquid paraffin, 0.4% tween 20 and 1.1% spin 20 were selected as the top formulation. The results of stability, dispersibility and other tests were appropriate. The amount of active ingredient in the formulations was between 90 and 110%. Within 8 hours, the drug was released at approximately 85%. Rheologically, the formulation followed non-Newtonian behavior. It also showed the behavior of plastics and thixotropes. Observing the growth inhibition zone around drug-containing formulations indicateed that mupirocin was released from the emulsion base and prevented the growth of Staphylococcus aureus bacteria.

    Conclusion

    A stable emulsion formulation can be prepared from mupirocin. It is suggested that accelerated stability studies and periodic and scale-up formulations be carried out for industrial production.

    Keywords: Emulsion, Topical, Dermal, Mupirocin}
  • جانسون ایساک*، عایشا دابوری، کنچوکوو بن، اومه، بنت ایفانی، فیلیپ بیلدرز
    Johnson Isaac *, Aisha Daburi, Kenechukwu Ben-Umeh, Benneth Ifeanyi, Philip Builders
    Background & Aim

    Since ancient times till today, honey and shea butter are used in wound treatment. This present study aims to determine an effective hydrophile-lipophile balance (HLB) value that will produce a stable W/O honey-shea butter emulsion and to evaluate its healing potential on chemical burn wound in mice.

    Experimental

    Using various ratios of span 20/tween 20, 6 formulations of honey-shea butter emulsion were prepared and subjected to accelerated stability study as per ICH guideline. The most stable preparation was further evaluated for its wound healing ability. The animals were sacrificed via chloroform inhalation after treatment for 7 days from wound created by dropping 0.2 ml, hydrochloric acid for 15 sec. The burn area was harvested and subjected to histopathological study.

    Results

    Most stable emulsion was those prepare with ratio 5:5 of span 20/ tween 20. Haematoxylin-eosin and Verhoeff-Van Gieson stain revealed that groups treated with this emulsion had normal fibroblast, fibrocyte, epidermal cells, inflammatory cells, gland cells, collagen and elastic fibres; outperforming honey, shea butter and silver sulfadiazine groups. The present formulation gave a percent wound contraction of 36, while those of honey, shea butter, silver sulfadiazine were 29, 25 and 28, respectively. The occlusive effect of emulsion and the synergistic effect achieved by combining honey and shea butter could also be responsible for its superior wound healing activity.

    Recommended applications/industries

    Our study concluded that honey-shea butter prepared with 5:5 span 20/tween 20 was relatively stable and possesses greater wound healing activity compared to commercial preparation and can safely be utilize as an effective natural therapy for burn wound.

    Keywords: Emulsion, Hydrophile-lipophile balance, Accelerated stability, Wound}
  • Sh. Dadkhah *, P. Damanafshan, A. Taheri Yeganeh, P. Homati

    Mayonnaise is a semisolid emulsion that is made by mixing oil with mustard, egg yolk, vinegar and is sensitive to spoilage due to its high polyunsaturated fatty acids content. The amount of oil and egg yolk added, viscosity, water quality, the volume of oil and aqueous phase, method of mixing and temperature affect the stability of mayonnaise. Phase inversion occurs when the emulsion changes from the oil-in-water (O/W) emulsion to the water-in-oil (W/O) emulsion. Egg yolk as an emulsifier has surface-active fractions such as livetin, lipovitellin, lipovitellenin that prevent coalescing and improve the texture. Phospholipid lecithin, proteins, and lipoproteins are known to be the most important to the emulsion forming properties of egg yolk. Other emulsifying agents include animal proteins, vegetables protein isolates, modified starches and gums which can be effectively used as food emulsion stabilizers because of their capacity to reduce the interfacial tension between hydrophobic and hydrophilic components. Temperature, pH and NaCl are effective on viscoelasticity of mayonnaise emulsion. Emulsifiers increase the prevalence of metabolic diseases, specially type 1 and 2 diabetes, obesity and irritable bowel disease. Currently the tendency of the consumers to purchase the food products with low fat and low energy is led to reformulation that often requires moving from one sort of emulsifier to another. In this study, different emulsifiers and their effects on the characteristics of mayonnaise were reviewed.

    Keywords: Mayonnaise, Emulsion, Emulsifiers, Egg Yolk, Stability}
  • M. Radi *, S. Amiri, F. Bagheri

    The aim of this research was to assess the effect of fat type and concentration as well as the continuous phase viscosity on the rheological properties of an oil-in-water (O/W) emulsion. Thus, sunflower oil and tallow fat were used as the dispersed phase of the emulsion both at 10 and 50% (w/v) and CMC solutions (at 0.1, 0.3 and 0.5% w/v) were acted as the continuous phase. CMC solutions and emulsions showed a shear-thinning behavior with increasing CMC or dispersed phase concentration. The rheological behavior of all samples was well modeled by Herschel-Bulkley, Power law and Casson equations. According to Herschel-Bulkley and Power law models, an increase in the consistency index and a decrease in the flow behavior index of all samples was occurred with increasing CMC concentration (0.1 to 0.5%), fat concentration (10 to 50%) and dispersed phase change from liquid oil to a solid fat. The obtained data were compared with Einstein, Larson, Pal and Dougherty-Krieger predicting models and the results showed that Larson model well described the flow behavior of emulsions with 10% fat content, and Dougherty and Krieger or Pal equations were fitted more with the experimental data of emulsions containing 50% fat content.

    Keywords: Emulsion, Fat Type, Modeling, Rheology}
  • Lieu My Dong*, Le Thi Hanh Quyen, Truong Duc Thang, Dang Thi Kim Thuy
    Background

    The present study aimed to investigate the effects of various encapsulation methods on Lactobacillus acidophilus viability using wall materials variably.

    Methods

    L. acidophilus was encapsulated using the extrusion and emulsion encapsulation methods with calcium-alginate and skim milk via mixing or coating. The particle size, encapsulation yield, and viability of L. acidophilus in the simulated gastric and intestinal fluids were investigated.

    Results

    The mean particle size in the emulsion and extrusion methods was within the range of 161 µm to1.95 mm, and the coated samples were smaller than the mixed samples. The encapsulation yield of the extrusion method was higher compared to the emulsion method. In addition, skim milk was essential to improving the L. acidophilus viability, which significantly improved in the calcium-alginate particles coated by skim milk compared to the mixed samples.

    Conclusion

    According to the results, the coating process by skim milk not only improved probiotic viability, but it also reduced the preparations particle size, which in turn decreased the adverse effects of the preparations on the sensory properties of food.

    Keywords: Emulsion, Encapsulation, Extrusion, Lactobacillus acidophilus, Skim milk}
  • Hamidreza Kazemeini *, Asghar Azizian, MohammadHassan Shahavi

    This research aimed to assess the effect of biodegradable coating chitosan nano-gel/emulsion loaded by Bunium persicum essential oil and nisin on E. coli O157:H7 in rainbow trout fillet during 12 days at refrigeration (4˚C). Trout fillet Sample was divided into 6 groups after inoculation of bacteria (E. coli O157:H7), including control (without any coating), coated with chitosan 2% and other groups including nano-emulsion chitosan 2%, Nano-emulsion of chitosan containing Bunium persicum essential oil (0.5%), Nano-gel of chitosan containing nisin (200 IU/g) and Nano-gel/emulsion of chitosan containing Bunium persicum essential oil (0.5%) and nisin (200 IU/g). The samples were stored at the cool condition, and the bacterial count was performed on days: 0, 1, 2, 4, 8, and 12. The mean number of the bacterial count was significantly different among treatment (p<0.001). The most significant inhibitory effect on the growth of E.coli O157:H7 was observed in chitosan Nano-emulsion coating containing Bunium persicum essential oil (0.5%) and nisin (200 IU/g). According to this study, it was concluded that the use of Nano-gel/emulsion of chitosan coating Bunium persicum essential oil and nisin could be effective on the decrease of E.coli O157:H7 growth in food.

    Keywords: Biodegradable Coating, Chitosan, Nano-Gel, Emulsion, essential oil, E.coli O157:H7}
  • Abdolreza Kazemi Abadshapoori, Yousef Kazemzadeh *, Mohammad Sharifi, Masoud Riazi
    Oil production from oil reservoirs containing oil in water (O/W) and water in oil (W/O) emulsions has always been accompanied by some problems. The increase in apparent viscosity of the oil, pore throats blockage, and consequently, the increased rate of pressure drop are among these problems. Investigating the behavior of this type of oil in the porous medium can help to understand the problem. Although metal oxide nanoparticles can increase the oil recovery and therefore improve the performance of reservoirs, they can result in the formation of W/O emulsions, due to their potential properties. In this study, the formation and stability of the emulsion were first evaluated and then the nanofluids were injected into a carbonate sand pack. Tests were conducted in the ambient condition. The amount of produced oil in the presence of three nanoparticles consist of TiO2, SiO2, and Fe3O4 has been investigated. Moreover, the effect of water injection on the system containing emulsions created by both different ions present in the seawater and iron oxide nanoparticles has been investigated. The results show that the iron oxide nanoparticles cause high-pressure oscillations by forming more stable emulsions in the porous media.
    Keywords: Ambient Condition, Emulsion, Metal Oxide Nanoparticles, Pressure drop, Water Flooding}
  • Swati Jagdale *, Saylee Pawar
    Purpose
    Ofloxacin is a fluoroquinolone with broad-spectrum antibacterial action, used in treatment of systemic and local infections. Ofloxacin is BCS class II drug having low solubility, high permeability with short half-life. The present work was aimed to design, develop and optimize gellified emulsion of Ofloxacin to provide site targeted drug delivery. Transdermal drug delivery will enhance the bioavailability of the drug giving controlled drug release.
    Methods
    Transdermal drug delivery system was designed with gelling agent (Carbopol 940 and HPMC K100M), oil phase (oleic acid) and emulsifying agent (Tween 80: Span 80). Effect of concentration of gelling agent on release of drug from transdermal delivery was studied by 32 factorial design. Emulgel was evaluated for physical appearance, pH, drug content, viscosity, spreadability, antimicrobial activity, in- vitro diffusion study and ex-vivo diffusion study.
    Results
    FE-SEM study of the emulsion batch B5 has revealed formation of emulsion globules of approximately size 6-8 µm with -11.2 mV zeta potential showing good stability for the emulsion. Carbopol 940 had shown greater linear effect on drug release and viscosity of the formulations due to its high degree of gelling. In-vitro diffusion study through egg membrane had shown 88.58±1.82 % drug release for optimized batch F4. Exvivo diffusion study through goat skin indicated 76.68 ± 2.52% drug release.
    Conclusion
    Controlled release Ofloxacin emulgel exhibiting good in-vitro and ex-vivo drug release proving good antimicrobial property was formulated.
    Keywords: Emulgel, Transdermal, Delivery, Ofloxacin, Antimicrobial, Emulsion}
  • هاجر یوسفی، صبیحه سلیمانیان زاد، محمد شاهدی باغ خندان
    سابقه و هدف
    به دلیل حرارت بالای پخت نان و مرگ پروبیوتیک ها در طول پخت، تهیه نان پروبیوتیک حاوی باکتری های زنده گسترش چندانی نیافته است. در این تحقیق، برای افزایش زنده مانی پروبیوتیک ها حین پخت نان، از ریزپوشانی به روش امولسیون استفاده می شود.
    مواد و روش ها
    باکتری لاکتوباسیلوس پلانتاروم A7 با غلظت های مختلف آلژینات سدیم و نشاسته ذرت ریزپوشانی شد. ریزپوشینه ها با اجزای خمیر، مخلوط و نان تهیه شد. pH نان و تعداد باکتری های پروبیوتیک زنده پس از پخت نان تعیین شد. اندازه ذرات ریزپوشینه ای که بیشترین تعداد باکتری زنده را در نان حفظ کرده بود؛ تعیین شد. همچنین بافت نان در سه زمان 0، 24 و 48 ساعت پس از پخت، در دمای 25 درجه سانتی گراد ارزیابی گردید.
    یافته ها
    pH نان در محدوده مناسب برای زنده مانی پروبیوتیک ها و پایداری ریزپوشینه ها قرار داشت. ریزپوشانی تاثیر معنی داری در زنده مانی پروبیوتیک ها حین پخت نان، داشت (05/0p<) و تعداد باکتری های زنده را نسبت به نمونه شاهد، بین 2-1 سیکل لگاریتمی، افزایش داد. بیشترین تعداد باکتری زنده در نان، 70/5 سیکل لگاریتمی بود که تا میزان لازم برای ایجاد خواص پروبیوتیک، اختلاف کمی داشت (6 سیکل لگاریتمی). اندازه ذرات این ریزپوشینه، 34/29 ± 85/329 میکرومتر بود. همچنین وجود ریزپوشینه ها، باعث نرم تر شدن بافت نان، نسبت به نمونه شاهد گردید (05/0p<).
    نتیجه گیری
    روش امولسیون ضمن حفظ کیفیت مناسب در نان، می تواند به عنوان روشی برای افزایش زنده مانی پروبیوتیک ها در نان، مد نظر قرار گیرد.
    کلید واژگان: پروبیوتیک, نان, ریزپوشانی, امولسیون, آلژینات سدیم}
    H. Yousefi, S. Soleimanian, Zad, M. Shahedi Bagh Khandan
    Background And Objectives
    Due to the high temperature and destruction of probiotics during baking, production of probiotic breads containing the viable bacteria has not been fully developed. In this study, to increase the viability of probiotics during bread baking, microencapsulation by emulsion method was used.
    Materials And Methods
    L. plantarum A7 was encapsulated by different concentrations of sodium alginate and corn starch. The microcapsules were mixed with dough ingredients, and the bread was prepared. The breads’ pH and viable counts of probiotic bacteria were determined after baking. The particle size of microcapsule that kept the highest number of live bacteria in the bread was measured. Also the breads’ texture at 0, 24 and 48 h storage (25°C) was evaluated.
    Results
    The obtained pH of breads was in the proper range to viability of probiotics and stability of microcapsules. The microencapsulation had significant effect on the viability of probiotics during bread baking (p
    Conclusion
    The microencapsulation by emulsion method can be considered as an alternative to increase the viability of probiotic in bread with appropriate characteristics during storage.
    Keywords: Probiotic, Bread, Microencapsulation, Emulsion, Sodium alginate}
  • Eskandar Moghimipour, Anayatollah Salimi, Masoud Karami, Sara Isazadeh
    Background
    The increased incidence of inflammatory diseases has necessitated the need to search for new topical dosage form of dexamethasone..
    Objectives
    The purpose of the present study was the preparation and evaluation of novel microemulsion as a topical delivery system for dexamethasone by mixing appropriate amount of surfactant including Tween 80 and Labrasol, cosurfactant such as capryol 90 and oil phase including labrafac lipophile wl-transcutol P (10:1 ratio)..
    Materials And Methods
    The prepared microemulsions were evaluated regarding their particle size, zeta potential, X-Ray scattering, conductivity, stability, viscosity, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), refractory index (RI), pH, and x-ray diffraction (XRD)..
    Results
    The results showed that the maximum oil was incorporated in microemulsion system that contained surfactant to cosurfactant ratio of 4:1. The mean droplet size range of microemulsion formulation was in the range of 5.09 to 159 nm, and its refractory index (RI) and pH were 1.44 and 7, respectively. Viscosity range was 57-226 cps. Drug release profile showed that 48.18% of the drug released in the 24 hours of experiment. Also, Hexagonal, cubic and lamellar structures were seen in the SEM photograph and XRD peak of microemulsions..
    Conclusions
    This study demonstrated that physicochemical properties and in vitro release were dependent upon the contents of S/C, water, and oil percentage in formulations. SAXS technique and SEM obtained important information about microstructure of microemulsions. W/O and bicontinuous microemulsion with different microstructures were found in formulations..
    Keywords: Dexamethasone, Emulsion, Calorimetry, Differential Scanning}
  • Arash Dabbaghi, Ali Shokraneh, Nastaran Farhadi
    Background
    Conventional tomography used for evaluation of the small areas of the jaws provides acceptable information. It has some advantages of availability, less radiation dose and costin comparison to computed tomography (CT) and cone beam CT. Double emulsion film usuallyused for taking tomograms requires less exposure than single emulsion film; on the other hand,the latter provides more sharpness and spatial resolution. The aim of this study was to comparediagnostic accuracy of these two kinds of films in the spiral tomography.
    Materials And Methods
    In an experimental study, 20 lines (10 lines anterior and 10 lines posterior to the mental foramen) were selected on two dry human mandibles and tomographic images were taken from each line with and without metal marker by single and double emulsion films. For quantitative assessment, the mandibular width and length was identified and measuredon 80obtained tomograms. Afterwards, the mandibles were sectioned on each line and theiractual width and height were measured. For each line, the data of tomograms were subtractedfrom gold standard as measurement error. These errors were divided into three groups: Greaterthan +1 mm, between +1 mm and −1 mm and less than −1 mm. Obtained data were analyzed byPearson Chi‑square test (α=0/05).
    Results
    There was no significant difference between the single and double emulsion films, withand without markers in the measurement of both height and width of mandible (P > 0.05).
    Conclusion
    The single emulsion film is not recommended to be used for taking the spiral tomogram.
    Keywords: Emulsion, tomography, X‑ray film}
  • مینا همایونفال، فرامرز خداییان*، سید محمد موسوی، سید محمد حسینی پنجکی
    سابقه و هدف
    روغن گردو به دلیل غنی بودن از اسیدهای چرب غیر اشباع امگا 3 و ترکیبات آنتی اکسیدانی، دارای خواص تغذیه ای فراسودمند شامل بهبود سیستم گوارشی، کاهش کلسترول خون و نهایتا کاهش بیماری های قلبی و عروقی است. در پژوهش حاضر امکان تولید نانوامولسیون بر پایه روغن گردو و تاثیر عوامل مختلف بر پایداری آن بررسی می شود.
    مواد و روش ها
    روغن گردو همراه با توئین 80 و اسپن 80 (به عنوان امولسیفایر) در تهیه نانو امولسیون استفاده شد. به منظور همگن سازی ذرات امولسیون از امواج فراصوت استفاده و تاثیر زمان همگن سازی، غلظت روغن و غلظت امولسیفایر بر قطر ذرات، پایداری و نرخ کاهش کدورت امولسیون بررسی شد.
    یافته ها
    اثر زمان همگن سازی، غلظت روغن و غلظت امولسیفایر بر ویژگی های امولسیون به وسیله نمودارهای سطح پاسخ ارزیابی و برای هر پاسخ مدل چند جمله ای درجه دو بدست آمد. نمونه های تولیدی دارای اندازه ذارت بین 450-300 نانومتر، پایداری %100-6/96 و نرخ کاهش کدورت 0021/0-0016/0 بودند.
    نتیجه گیری
    در این مطالعه مشخص شد می توان از روغن گردو امولسیون هایی در محدوده نانو تولید کرد و ارزیابی امولسیون ها توسط تست خامه ای، شدن بیانگر پایداری فیزیکی مناسب نمونه ها در طول دوره نگهداری (84 روز) است.
    کلید واژگان: امولسیون, پایداری, روغن گردو, روش سطح پاسخ, کدورت}
    M. Homayoonfal, F. Khodaiyan *, M. Mousavi, M. Hosseini Panjaki
    Background And Objective
    Walnut oil has a high omega-3 unsaturated fatty acid and antioxidant component content، providing nutritional and functional properties including improvement of the gastrointestinal system، decrease in blood cholesterol level، eventually leading to a decrease in the risk of cardiovascular disease. The present study examined the possibility of the production of emulsion based on walnut oil and the effect of preparation on its stability.
    Materials And Methods
    Walnut oil with tween 80 and span 80 (as emulsifiers) was used in emulsion production. Ultrasonic waves were applied for homogenization and the effect of homogenization time، oil content، and emulsifier concentration on particle size، emulsion stability، and turbidity loss rate was studied.
    Results
    Ultrasonic time had a reverse effect on particle size and turbidity loss rate and a direct effect on emulsion stability. The particle size and turbidity loss rate of prepared emulsions had a direct relation with oil concentration and a negative effect on emulsion stability. Emulsifier concentration had a positive effect on emulsion stability، a negative effect on emulsion stability، and had no significant effect on turbidity loss rate.
    Conclusion
    Walnut oil can be used to produce emulsions with high stability; an evaluation of emulsion stability using creaming tests showed that samples have appropriate stability during storage time.
    Keywords: Emulsion, Stability, Walnut oil, Response surface methodology, Turbidity}
نکته
  • نتایج بر اساس تاریخ انتشار مرتب شده‌اند.
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