جستجوی مقالات مرتبط با کلیدواژه « Follicular » در نشریات گروه « پزشکی »

Folliculotropic mycosis fungoides (FMF) is a rare variant of cutaneous T-cell lymphoma which is categorized as a separate entity. In histopathology, malignant lymphocytes selectively surround and infiltrate hair follicles. FMF has different clinical features in comparison with classic MF which is more refractory to treatment and has a worse prognosis.In the current study, we describe a 42-year-old patient presenting as follicular papules with keratotic spines and alopecia on the scalp, face, and trunk. Histologic examination of the patient’s biopsy revealed follicular and perifollicular T lymphoid cell infiltration without follicular mucinosis. Clonality analysis was interpreted as CD4+ T cell lymphoproliferative disorder. With the final diagnosis of FMF, the patient underwent treatment with oral acitretin and topical corticosteroid and psoralen plus ultraviolet A (PUVA). This case, in addition to the accompanied review of literature, revealed the importance of considering FMF in spiny hyperkeratotic papules in seborrheic areas refractory to antifungal treatments.

The use of anti-CD20 monoclonal antibodies like rituximab (RTX) to deplete B cells has practical therapeutic implications in multiple sclerosis (MS) patients. However, the therapy's impact on other immune cells is al so important. Therefore, in this study, we assessed the effects of RTX therapy on Tfh cells, T cells, T cells priming, and monocytes in MS patients compar ed to newly-diagnosed MS patients and healthy subjects.

 Thirty newly-diagnosed and RTX-treated MS patients and healthy control were included. Peripheral blood mononuclear cells were isolated from whole blood for assessment of Tfh cells, CD4 + , CD8 + , CD4 + CD45RA+ , CD3 + HLA-DR+, and CD3 + CD4+ CD25 + T cells by flow cytometry. Whole blood was lysed by lysis solution to assess CD45+ CD14+ monocytes by flow cytometry. Also, the serum level of interleukin 21 was measured by the ELISA method.

We showed that RTX treatment led to a de crease in Tfh cells and their predominant cytokine, interleukin 21. Also, we found a statistically significant reduction in CD3 + HLA-DR+ and CD3 + CD4+ CD25 + T cells in RTX-treated patients compared to new cases and healthy control. Moreover, we found a decrease in the CD45+ CD14+ monocyte population in the RTX-treated group compared to the healthy control.

 Our data suggest that following treatment with RTX, Tfh cells, monocytes, and T cells priming declined happened, and fewer T cells were activated. Also, due to the interaction between B cells and Tfh cells, Tfh targeting could be assessed as a therapeutic strategy in MS

Follicular lymphoma (FL) is the second most common adnexal lymphoma of the eye that almost all of them are reported in elderly patients. Primary FL of the eye has been reported in only two children. Pediatric FL appears to be biologically distinct from typical adult FL. In cases without other organ involvement excision alone with close monitoring is a treatment of choiceand the prognosis is excellent.

A 12 year -old male with a nodular lesion involving the inner can thus of the right eye was admitted to ophthalmology clinic. The lesion was painless and the nodule size gradually increased over a period of 6 months.Excisional biopsy demonstrated follicular lymphoma composed of neoplastic lymphoid cells which arranged in follicular pattern without germinal centers. Neoplastic cells were positive for Bcl2 and CD20.

Although follicular lymphoma of the conjunctiva is rare in childhood but it could be considered as one of the differential diagnosis in this age group.