جستجوی مقالات مرتبط با کلیدواژه « Immunomodulatory Effects » در نشریات گروه « پزشکی »

Cancer therapy necessitates innovative approaches with enhanced efficacy and reduced side effects. Essential oils have gained attention because of their diverse biological properties and relatively low toxicity. Zataria multiflora essential oil (ZEO) and Oliveria decumbens essential oil (OEO) exhibit promising anti-cancer effects, particularly in modifying oxidative stress and inflammation. Both oils boast complex compositions rich in bioactive compounds, including oxygenated monoterpenes and phenolic compounds like carvacrol and thymol. Hence, this study investigates essential oils’ anti-cancer, anti-oxidant and immunomodulatory effects, focusing on ZEO and OEO.

This review briefly considers the intricate mechanisms of several essential oils, encompassing anti-oxidant, anti-inflammatory and anti-cancer properties. Then the review delves into the multifaceted mechanisms underlying the anti-cancer properties of ZEO and OEO. 

Studies showcase the ability of ZEO and OEO to induce apoptosis in cancer cells through various pathways, such as mitochondrial dysfunction, reactive oxygen species (ROS) generation and DNA damage while sparing normal cells. Our studies further validated the immunomodulatory effects of OEO and ZEO in tumor-bearing mice, resulting in reduced tumor volume. Additionally, this review confirmed the synergistic effect of ZEO when combined with doxorubicin to inhibit cancer cells. 

Some essential oils, such as ZEO and OEO, present promising natural compounds in cancer therapy, offering diverse mechanisms of action targeting various aspects of tumor biology.

The SARS-CoV-2 virus is a member of the coronavirus family that caused the COVID-19 respiratory disease epidemic in China before the global pandemic of the disease in late 2019. The virus's genome is of 79% similarity to that of the SARS-CoV virus, using the ACE2 receptor to enter its target cells. The most common symptoms of this disease include fever, cough, pulmonary involvement, and sometimes gastrointestinal symptoms. A decline in both the number and function of lymphocytes and a severe increase in leukocyte inflammatory activity are among the most obvious immunological complications of this disease. If the immune system response to the virus is inadequate, the disease can become acute. Immune cells activity leads to a sharp increase in the number of blood cytokines, causing "cytokine storm," which in turn can cause systematic damages to the heart, lungs, and kidneys, and ultimately may lead to death. Mesenchymal stem cell therapy offers a promising approach to reducing the destructive impacts of infection in patients with COVID-19. Mesenchymal stem cells can secrete immune-modulating factors that suppress cytokine storms. Furthermore, the role of mesenchymal stem cells in preventing cell death and inhibiting tissue fibrosis has been well demonstrated. This review shows available clinical trials that have tapped into the therapeutic potential of the umbilical cord mesenchymal stem cells in patients with COVID-19.