جستجوی مقالات مرتبط با کلیدواژه « Late complications » در نشریات گروه « پزشکی »
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سابقه و هدف
با توجه به سرایت بالای ویروس کرونا و شیوه انتقال آن از طریق لمس کردن سطوح آلوده و سپس لمس چشم، بینی یا دهان، کارکنان بهداشتی از بالاترین خطر آلودگی برخوردار هستند، درنتیجه واکسیناسیون این نیروی کار ضروری است. اما این واکسیناسیون عوارض شایع موضعی و سیستمیک نیز در پی داشت، لذا مطالعه حاضر با هدف بررسی عوارض زودرس و دیررس ناشی از دوزبوستر واکسن آسترازنکا در پرسنل و کادر درمان مرکز آموزشی درمانی رازی قایمشهر انجام شده است.
مواد و روش هااین مطالعه به روش مقطعی توصیفی بر روی تمامی کارکنان مرکز رازی قایم شهر در سال 1400 انجام شد. افراد به روش سرشماری و در دسترس انتخاب شدند. ابزار مورد استفاده پرسشنامه مربوط به سوالات زمینه ای و تخصصی عوارض دوز بوستر واکسن بود. داده ها توسط آزمون کای اسکویر و رگرسیون لجستیک دوحالتی تحلیل شدند.
یافته ها302 کارمند بهداشتی که دوز بوستر واکسن آسترازنکا را دریافت کرده بودند در این مطالعه شرکت داشتند. شرکت کنندگان با میانگین سنی 34/89 سال متغیر بودند و 37/7 درصد مرد و 62/3 درصد زن بودند. شایع ترین عوارض جانبی واکسن شامل درد 64/2 درصد، خستگی 58 درصد و تب 54/6 درصد گزارش شد. شرکت کنندگان تا دو ماه از نظر عوارض دیررس شامل سکته قلبی، سکته مغزی و آمبولی ریه بعد از تزریق دوز بوستر آسترازنکا تحت نظر بودند که گزارشی مبنی بر عوارض دیررس ذکر نشد.
استنتاجبا توجه به نتایج این پژوهش، به دلیل امکان وقوع بیش تر عوارض سیستمیک نظیر درد عضلانی، خستگی، سرفه و تب پس از تزریق، کارکنان بهداشتی درمانی باید توجه ویژه ای به عوارض زودرس واکسن داشته باشند.
کلید واژگان: عوارض زودرس و دیررس, واکسن آسترازنکا, پرسنل و کادر درمان}Background and purposeDue to the high spread of the coronavirus and the mode of transmission through touching contaminated surfaces and then touching the eyes, nose, or mouth, health workers have the highest risk of contamination, and vaccination of this workforce is necessary to reduce the risk, but this vaccination also resulted in high and common side effects such as local, systemic, early and late side effects. Therefore, the present study was conducted to investigate the early and late complications caused by the booster dose of the AstraZeneca vaccine in the personnel and medical staff of Razi Ghaemshahr Medical Training Center.
Materials and methodsThis descriptive cross-sectional study was conducted on all personnel and treatment staff of Razi Ghaemshahr Center in 1400. Participants were selected by convenience sampling method and a questionnaire related to the topical and specialized questions about booster vaccine side effects was used to collect the data. The data were analyzed using chi-square test and two-way logistic regression.
Results302 health workers who received a booster dose of the AstraZeneca vaccine participated in this study. The participants had an average age of 34.89, 37.7% were men and 62.3% were women. The most common side effects of the vaccine include pain 64.2%, fatigue 58% and fever 54.6%. The participants were monitored for two months in terms of late complications, including heart attack, stroke, and pulmonary embolism after injecting a booster dose of AstraZeneca, and there were no reports of late complications.
ConclusionAccording to the results of this research, due to the possibility of more systemic side effects such as muscle pain, fatigue, cough, and fever after the injection, healthcare personnel should pay special attention to the early side effects of the vaccine.
Keywords: Early, Late complications, AstraZeneca vaccine, personnel, treatment staff} -
Introduction
Irradiation to treat head and neck cancer, causing chronic tissue damage, is associated with the development of vascular disease. Interest has risen over the effects of radiotherapy on major vessels, due to its high morbidity and mortality rate. However, small-vessel disease has been poorly studied and described.
Case Report:
We present a case of a patient with bilateral necrosis of the anterior third of the tongue, occurring 3 years after chemoradiotherapy treatment for squamous cell carcinoma of the floor of the mouth. Contrast-enhanced CT scan showed multiple areas of stenosis concerning both external carotid arteries and their branches, and total opacification of lingual arteries. Conservative management was performed, with auto-amputation on the fifth day, which allowed healing by secondary intention.
ConclusionsNecrosis of the tongue appears as a rare late complication of radiotherapy, possibly due to its acceleration effect on the atherosclerosis process. Following small-vessel disease, one can assume a higher potential risk of major-vessel disease, highlighting the importance of a routine assessment and prophylaxis of thrombotic events.
Keywords: late complications, Radiotherapy, small-vessel disease, Tongue necrosis} -
Introduction
Recent Developments in cancer treatment could provide a better survival rate for Acute Lymphoblastic Leukemia (ALL) patients. Survivors faced different long term complication after treatment, for instance cardiac, neurologic and kidney complications. Assessment of the late complications could be useful in the optimization of treatment protocols. The objective of this study was to evaluate the late kidney complications, renal function in ALL patients after therapy.Material &
MethodsIn this study, we used 46 children. The treatment preformed based on ICBFM protocol. The mean age at the start of the treatment was 53±23 and the mean follow up time was 48±11 months. The tubular damage in these patients was evaluated by urinary NGAL level and the renal function was assessed by GFR.
Resultsin this study 56.7% of the patients were male. The NGAL level shows abnormally high in 8.9% of patients and the mean urine NGAL was 63±113ng/mL. Also, the mean GFR at the time of the diagnosis and at the time of the start of the follow up were 102.8 ±25.6 mL/min/1.73 m2 and 93.6 ±29.1 mL/min/1.73 m2, respectively. The study indicated GFR were less than 60 mL/min/1.73 m2 in 13.3% of patients.
Conclusionthis study indicated the long term follow up of the ALL survivors for kidney disorders are an important manner. The urinary NGAL level shows that 8.9% of the patients are tubular damage by using this treatment protocol. The study concluded that ICBFM protocol is a safe protocol with little long term damage.
Keywords: Survivorship, Late complications, Renal diseases, ALL} -
International Journal of Hematology-Oncology and Stem Cell Research, Volume:10 Issue: 1, Jan 2016, PP 1 -6BackgroundHematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for acute leukemia. As HSCT improves the long-term survival, it is necessary to assess the late-onset complications affecting the quality of life following HSCT.
Subjects andMethodsThe study included 122 patients (65 male, 57 female) with leukemia (72 AML and 50 ALL) who received transplants from fully- matched siblings, unrelated donors and unrelated cord blood donors between February 2013 and August 2014 in Shariati Hospital. All study participants were over 18 years of age and had the minimum and maximum survival of 2 and 5 years, respectively. Patients who received HLA-haploidentical SCT were excluded from the study. All allogeneic recipients received busulfan and cyclophosphamide as conditioning regimen. Nobody received TBI-based conditioning regimen in this study.
Patients were evaluated for cardiovascular, vision, psychological, endocrine, fertility problems and secondary malignancies one year after transplantation.ResultsData were analyzed using SPSS 15.0. Mitral and tricuspid regurgitation (TR/MR) were the most common cardiac complications (n=12, 10.5%).Thirty-nine percent of patients had psychological problems, especially depression (34%). Cataract was observed in 13% of patients and 34% complained of dry eye. Symptomatic pulmonary changes were found in 13 patients (10.6%). None of the HSCT survivors had experienced fertility before study entry. According to LH and FSH levels, 15% and 9% of females had ovarian failure, respectively. Testosterone level was less than normal in 49(84%) men and, according to their FSH and LH level, 20 (41%) had secondary hypogonadism and 29 (59%) had primary gonadal dysfunction.ConclusionThe results showed that patients who received Bu/Cy conditioning regimen experienced fewer late side effects such as cataract formation and hypothyroidism, compared to previous studies using TBI-based conditioning regimen.Keywords: Hematopoietic Stem Cell Transplantation (HSCT), Late Complications, TBI, BuCy Regimens}
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