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عضویت

جستجوی مقالات مرتبط با کلیدواژه « assisted » در نشریات گروه « پزشکی »

  • Andrey Gaiday, Akylbek Tussupkaliyev, Abay Nurken, Assel Gaiday, Ainur Primbetova, Moldir Dossimbetova, Assemgul Yeszhanova, Bibigul Karimsakova, Nurgul Ablakimova *

    The incidence of ectopic pregnancy (EP) has increased in recent years, owing to causes such as pelvic inflammatory diseases and assisted reproductive technologies (ART). The present study reported a case of a 33-year-old nulliparous woman with a history of previous ectopic pregnancies, who underwent pelvic ultrasound in August 2022, which revealed a double EP including a cervical pregnancy and a tubal stump pregnancy. Despite known risk factors and elevated beta-human chorionic gonadotropin (β-hCG) levels, a conservative approach, utilizing multiple doses of systemic methotrexate (MTX) injections, was employed to preserve fertility at the Regional Perinatal Center in Aktobe, Kazakhstan. Treatment efficacy was monitored through β-hCG levels and ultrasound imaging, with successful resolution of both EPs and preservation of reproductive function. The present case highlighted the safety and efficacy of MTX therapy in managing complex EP presentations, emphasizing the necessity of individualized treatment approaches in reproductive medicine, particularly in terms of preserving fertility in patients undergoing ART. Multiple high doses of MTX injections were beneficial for pregnancy with two distinct regions, fetal cardiac activity, and elevated serum β-hCG level. Further research is required to explore optimal treatment strategies for EP, considering patient-specific factors and treatment goals.

    Keywords: Pregnancy, Ectopic, Methotrexate, Reproductive Techniques, Assisted}
  • Sepideh Omidvar, Kamal Mostafanezhad, Ahad Zeinali *
    Introduction
    Due to the challenge of choosing the optimal treatment regimen as well as the accurate dose calculation algorithm (DCA), this study aimed to evaluate the DCAs to compare the conventional fractionation radiotherapy (CFRT) and hypofractionation radiotherapy (HFRT) of breast cancer (BC) in the prediction of cardio-pulmonary complications.
    Material and Methods
    For 19 patients with left-sided BC, treatment regimens, CFRT (50Gy/25frs) vs. HFRT (42.5Gy/16frs), were simulated. Normal tissue complication probability (NTCP) and tumor control probability (TCP) values for each regimen using radiobiological models were calculated via Monte Carlo (MC) and Collapsed Cone Convolution (CCC) algorithms. For statistical comparison of the results obtained from the regimens and algorithms, the t-test and Wilcoxon test were used in SPSS Statistics. Statistical significance was defined as p<0.05.
    Results
    The mean NTCP and TCP calculated in CFRT and HFRT were as follows: cardiac mortality (MC: CFRT=0.0374±0.0134 vs. HFRT=0.0173±0.0066; p<0.001) and (CCC: CFRT=0.0373±0.0134 vs. HFRT=0.0168±0.0064; p<0.001), pneumonitis (MC: CFRT=0.1201±0.0322 vs. HFRT=0.0756±0.0221; p<0.001) and (CCC: CFRT=0.1131±0.0310 vs. HFRT=0.0697±0.0120; p<0.010), and TCP (MC: CFRT=0.9979±0.0087 vs. HFRT=0.9997±0.0092; p=0.593) and (CCC: CFRT=0.9982±0.0029 vs. HFRT=0.9986±0.0016; p=0.821).
    Conclusion
    The comparison of CFRT and HFRT using MC and CCC algorithms showed that the risk of cardiac mortality and pneumonitis in CFRT was significantly higher than in HFRT, and TCP was not significantly different in the two regimens. Applications of MC-based DCAs along with suitable biological parameters can help physicists in the prediction of radiation-induced complications accurately and precisely.
    Keywords: Breast Neoplasms Pulmonary Heart Disease Radiation Dose Hypofractionation Radiotherapy Planning Computer, Assisted}
  • Mehran Anjomrooz, Maryam Farid Mojtahedi *, Mahboubeh Abedi

    Heterotopic pregnancy (HP) is a rare occurrence in natural pregnancies. However, it can be a life-threatening condition and should be taken into account in all assisted reproductive treatments. Diagnosis and treatment of ectopic pregnancy are challenging issues in patients with HP. Here, we report a rare case of quadruplet HP following an in vitro fertilization-embryo transfer with a viable twin intrauterine pregnancy and ruptured live twin left tubal ectopic pregnancy. A 35-year-old woman (gravida 5, para 1, ectopic pregnancies 2, and abortion 1) was presented to the Emergency Department of Arash Women’s Hospital (Tehran, Iran) in March 2021 with abdominal pain. The patient was at six weeks and five days of pregnancy following in vitro fertilization-embryo transfer. Transvaginal sonography (TVS) revealed a live twin intrauterine pregnancy with a ruptured live twin left tubal ectopic pregnancy. The latter was removed via laparotomy to preserve the intrauterine pregnancy. The patient subsequently delivered a female infant at 38 weeks of pregnancy.

    Keywords: Reproductive Techniques, Assisted, embryo transfer, Fertilization in vitro, Quadruplets}
  • Masoomeh Latifi, Leili Allahbakhshian, Fatemeh Eini, Nader Alishan Karami, Mohammed Nasser Al‑Suqri
    Background

    Couples undergoing Assisted Reproductive Techniques (ART) come across various information needs. This study aimed to identify the health information needs of couples undergoing ART.

    Materials and Methods

    The methodology of the present applied study was qualitative and the research method was conventional qualitative content analysis performed with the participation of 25 infertile couples under ART. The study took nine months (July 2020 to March 2021). The samples were objectively screened based on the criteria from the couples referred to the infertility center affiliated to Hormozgan University of Medical Sciences (Public) and Ome‑Leila Specialized infertility clinic (Private) in Bandar Abbas (Iran). Data collection was performed by semi‑structured interviews. The typical content analysis method was used in this research. Data analysis was carried out based on coding by the use of MAXQDA a software for qualitative and mixed methods data analysis.

    Results

    Information needs of couples under ART were categorized into three main categories and ten subcategories: 1) main cause of infertility [feminine or masculine cause, and etiology (nature and origin)], 2) treatment of infertility [identifying ART, treatment success rate, complications and risks (outcomes) of the treatment method, and treatment duration], and 3) healthcare [advice on medication, healthy nutrition (diet), sexual relations, and daily routine].

    Conclusions

    The results of this study emphasize that the country’s health officials, especially those in charge of the healthcare of infertile couples under ART, must necessarily pay more attention to meeting the needs of this group of people in society.

    Keywords: Assisted, consumer health information, infertility, qualitative research, reproductivetechniques}
  • Fahime Valipour, Nazli Navali
    Objectives

    Today, infertility is a global complication affecting 8%-12% of couples. The use of assisted reproductive techniques (ARTs) gives couples to have taken the home baby chance. In this study, we compare the outcomes of the ARTs after using the standard dose of human chorionic gonadotropin (hCG) hormone and gonadotropin-releasing hormone (GnRh) agonist plus declined dose of hCG for final oocyte maturation in antagonist cycles.

    Materials and Methods

    This randomized clinical trial was conducted in Al-Zahra hospital, Tabriz, Iran from June to December 2019 on 100 infertile women who were candidate for in vitro fertilization in two groups: group A received standard dose of hCG and group B received GnRH agonist 0.2 mg and hCG 2500 international unit as dual trigger. The number of oocytes retrieved, embryo obtained, implantation rate, pregnancy rate, and ovarian hyperstimulation syndrome (OHSS) were compared between two groups.

    Results

    The number of retrieved oocytes in the group B was more than group A (P = 0.024), and the embryo obtained in both groups was similar. The implantation and pregnancy rate in the group B increased compared to group A (P = 0.001). There was no OHSS case in the group B, while in the group A two cases suffered from OHSS.

    Conclusions

    Dual trigger with GnRH agonist plus declined hCG dose increased the number of retrieved oocytes, implantation, and pregnancy rates and decreased the risk of OHSS compared to standard hCG trigger. The gynecologists should select the best strategy based on the patient’s condition.

    Keywords: GnRH agonist, Human chorionic gonadotropin hormone, Ovarian hyperstimulation syndrome, Reproductive techniques, Assisted}
  • Soudabeh Sabetian, Bahia Namavar Jahromi, Farnia Feiz, Isabella Castiglioni, Claudia Cava, Sina Vakili *
    Background

    The coronavirus disease-2019 (COVID-19), caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now spread  worldwide. Therefore, informative and reliable data related to the exact effects of COVID-19 on fertility and pregnancy is still of great interest until the pandemic is declared over. General guidelines regarding the protection and management of COVID-19 have been published and new information will continue to be updated daily.

    Methods

    In this review, we summarized clinical health guidelines for reproductive and infertility centers to improve quality management in assisted reproductive technology and minimize the potentially harmful consequences of COVID-19 on pregnancy and fertility.

    Results

    As specified in the literature, protocols consist of five categories, including protocols for couples, protocols for women, protocols for men, labor and delivery, and postpartum and breastfeeding.

    Conclusion

    General protocols for patients and staff may vary depending on specific conditions. However, this review provides some rules to ensure their safety against the disease during the pandemic.

    Keywords: Assisted, Assisted Reproductive Technology, COVID-19, infertility, Pandemic, Reproductive Techniques}
  • Jaimin Gamit, Shreekripa Rao, Jyothi N, Sarath Nair, Shambhavi Charan, Rechal Dsouza, Krishan Sharan, Srinidhi Chandraguthi *
    Introduction
    Elekta Versa HD linear accelerator is equipped with a universal wedge filter which is a single large physical wedge driven by motors; in other words, motorized wedge. It provides a nominal wedge isodose angle of 60° for the field size of 30×40 sq. cm. Motorized wedge isodose distribution generated is a combination of open and wedged beam segments. With this background in mind, the present study aimed to validate the planned wedge effective isodose angle.
    Material and Methods
    The current study validated the planned wedge effective isodose angle for  15°, 30°, 45°, and 60°  with 6MV and 15MV for 10x10 sq. cm and 20x20 sq. cm field size. To this end, an analytical formula was applied against a 2D array detector using PTW MultiCheck software.
    Results
    As illustrated by the obtained results, the calculated, measured, and planned wedge effective isodose angle in this work represented a maximum deviation from its pre-set angle (a nominal wedge angle) of  9° for a 6MV photon energy and 5° for 15MV for field sizes of 10×10 sq. cm and 20×20 sq. cm.
    Conclusion
    In the present study, we validated the planned wedge effective isodose angle for field sizes of 10x10sq. cm and 20x20sq. cm for 6MV and 15MV photon energies using an analytical method and 2D array detector with a reasonable agreement.
    Keywords: rays Radiometry Particle Accelerators Quality Control Radiotherapy Planning Computer, Assisted}
  • Ali Abbasian Ardakani, Afshin Mohammadi *, Akbar Gharbali, Aram Rostami
    Background
    Early detection and reliable diagnosis of breast cancer could lead to improved cure rates and reduce mortality and management costs.
    Objectives
    To explore the potential of texture analysis based on run-length matrix features for classifying benign and malignant breast tumors in ultrasound imaging.
    Methods
    A total of 70 breast tumors (38 benign and 32 malignant) have used in the proposed computer-aided diagnosis system. Twenty run-length matrix features have extracted for texture analysis in three normalizations (default, 3sigma, and 1% - 99%). Linear discriminant analysis and principal component analysis have employed to transform raw data to lower-dimensional spaces and increase discriminative power. The features have classified by the first nearest neighbor classifier.
    Results
    The features under 3sigma normalization have designed via Linear discriminant analysis indicated high performance in classifying benign and malignant breast tumors with a sensitivity of 96.87%, specificity of 100%, accuracy of 98.57%, positive predictive value of 100%, and negative predictive value of 97.43%. The area under receiver operating characteristic curve was 0.992.
    Conclusions
    Run-length matrix features had a high potential to characterize and could help radiologist to diagnosis breast tumors.
    Keywords: Breast Cancer, Computer, Assisted, Diagnosis, Ultrasonography}
  • Zahra Emrani, Soroosh Bateni, Hossein Rabbani
    Real-time image processing is used in a wide variety of applications like those in medical care andindustrial processes. This technique in medical care has the ability to display important patientinformation graphi graphically, which can supplement and help the treatment process. Medical decisionsmade based on real-time images are more accurate and reliable. According to the recent researches,graphic processing unit (GPU) programming is a useful method for improving the speed and quality ofmedical image processing and is one of the ways of real-time image processing. Edge detection is anearly stage in most of the image processing methods for the extraction of features and object segmentsfrom a raw image. The Canny method, Sobel and Prewitt filters, and the Roberts’ Cross technique aresome examples of edge detection algorithms that are widely used in image processing and machinevision. In this work, these algorithms are implemented using the Compute Unified Device Architecture(CUDA), Open Source Computer Vision (OpenCV), and Matrix Laboratory (MATLAB) platforms. Anexisting parallel method for Canny approach has been modified further to run in a fully parallel manner.This has been achieved by replacing the breadth-first search procedure with a parallel method. Thesealgorithms have been compared by testing them on a database of optical coherence tomography images.The comparison of results shows that the proposed implementation of the Canny method on GPU usingthe CUDA platform improves the speed of execution by 2–100× compared to the central processing unitbasedimplementation using the OpenCV and MATLAB platforms.
    Keywords: Algorithms, computer systems, computers, humans computer, assisted, image processing, optical coherence, tomography}
  • Mandana Naseri, Yazdan Shantiaee, Javid Rasekhi, Saeedeh Zadsirjan, Maryam Mojtahed Bidabadi, Akbar Khayat
    Introduction
    The conventional method of teaching endodontics has some drawbacks. Due to the small size of the oral cavity, students cannot closely observe the clinical procedure. Use of new teaching modalities such as the intraoral camera may obviate this problem. This study assessed the effect of video-assisted clinical instruction in dentistry (VACID) on dental student’s knowledge and performance in access cavity preparation during endodontic treatment.
    Methods and Materials: In this interventional study, twenty six undergraduate students were equally divided into two groups and received instructions on access cavity preparation via conventional demonstration (CD) or VACID using intraoral camera plus conventional demonstration. Students’ knowledge was assessed before and after the demonstration. The scores obtained by students were compared between the two groups. Data were analyzed using the Mann Whitney U test.
    Results
    No significant difference was found between the two groups in knowledge and performance scores of students about pulp chamber removal, under-extension, over-extension, gouging, perforation or finding the main and extra canals. However, use of intraoral camera significantly reduced the number of student visits to instructors for problem solving (P=0.001).
    Conclusion
    VACID is an effective educational method and as efficient as conventional demonstration in endodontics; as a result it can be used in combination with conventional teaching.
    Keywords: Conventional Education, Endodontic Treatment, Knowledge, Performance, Video, assisted}
  • A Comparison of Radiographic Film Densitometry Using a New Computerized Tool with a Digital Densitometer
    Hoorieh Bashizadeh Fakhar, Elham Sadat Emadian Razavi, Sepideh Soheilifar, Mohammad Javad Kharazifard
    Objectives
    The purpose of this study was to develop and test a new tool for radiographic densitometry by combining periapical films and aluminum step wedge.
    Materials And Methods
    We reviewed 50 Kodak E-speed intraoral films. An aluminum step wedge consisting of 16 steps was constructed. Each step was 1mmx3mx10mm. The step wedge was exposed to varying exposure times, ranging from 0.05 second to 0.5 second, increasing in 0.05 second increments. Films were digitalized after processing and the MATLAB software algorithm was ran subsequently. Density of the films was measured again using a digital densitometer. In order to compare the two imaging techniques, three steps were selected. Output data from the MATLAB algorithm were compared with data obtained from the digital densitometer.
    Results
    The new method could detect significant differences between subsequent exposure times in step 7, while the densitometer did that in steps 7 and 12. The new method’s sensitivity in determining density changes was 5.26%, 84.1% and 93.02% in steps 2, 7, and 12 respectively.
    Conclusions
    Our new method has an acceptable sensitivity for determining density changes of at least 7 mmEq/Al.
    Keywords: Densitometry, Image Processing, Computer, Assisted, Aluminum, Phantoms, Imaging}
  • Taraneh Taghavi Larijani, Nahid Dehghan Nayeri, Marjan Mardani Hamooleh *, Nasrin Rezaee
    Background And Aim
    Family psychological support is a highly important concept concerning patients diagnosed with cancer. The purpose of this study was to investigate cancer patients’ perceptions of family psychological support.
    Methods
    This study had a qualitative approach using inductive content analysis method. Through purposive sampling, 15 patients were selected who underwent semi-structured, face-to-face interviews. After data collection, all the interviews were transcribed and analyzed via content analysis.
    Results
    In general, 298 codes were extracted and categorized into two main themes: seeking support from family and valuing the patient as a family member. Seeking support from family composed of two subcategories, i.e., emotional support seeking and spiritual support seeking. Also, valuing the patient as a family member had two sub-categories consisting of unconditional acceptance and respect.
    Conclusion
    From the point of view of the participants, emotional and spiritual support seeking as well as unconditional acceptance and respect play a significant role in the psychological support of the families for these patients.
    Keywords: Neoplasms, Patients, Family, Suicide, Assisted}
  • Mahmoud Yolmeh *, Mohammad Bagher Habibi-Najafi, Shahrzad Shakouri, Fereshteh Hosseini
    Background
    Annatto dye is used extensively in food industry that has antibacterial and antioxidant properties.
    Objectives
    Aim of this paper was comparison of the antibacterial and antioxidant properties of annatto dye was extracted by conventional and ultrasound-assisted extraction (UAE) methods.
    Materials And Methods
    In this experimental study minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of annatto dye against the bacteria were determined by agar dilution method. Antioxidant activity of annatto dye was evaluated by DPPH method.
    Results
    Gram-positive bacteria show more sensitivity to annatto dye than Gram-negative bacteria. Annatto dye extracted by UAE has more antibacterial and antioxidant activity compared to conventional method. Bacillus subtilis and Escherichia coli have the highest and the lowest sensitivity to annatto dye, respectively.
    Conclusions
    Annatto dye extracted by UAE showed a bactericidal effect against Salmonella enteritidis, however the dye extracted by conventional method the opposite is true.
    Keywords: Annatto, Antibacterial, Antioxidant, Ultrasound, assisted}
  • Mehravar Rafati, Mehrdad Rafati Rahimzadeh, Fariba Raygan, Vahid Nikseresht, Hassan Moladoust
    Background
    Ultrasound measurement of carotid Intima-Media Thickness (IMT) is a suitable method to evaluate subclinical arteriosclerosis.
    Objectives
    The current study aimed to present a new computerized algorithm to detect instantaneous changes of the IMT to Common Carotid Artery (CCA) of IMT in sequential ultrasound images by applying the maximum gradient and the dynamic programming.Patients and
    Methods
    In a cross-sectional design, an examination was performed on thirty healthy human subjects with the mean age of 44 ± 6 years from April 2013 to June 2013 in Beheshti Hospital, Kashan, Iran. In all individuals, the instantaneous changes of the far wall IMT on the CCA were extracted. Local measurements of vessel intensity, intensity gradient, and boundary continuity were extracted for all of the sequential ultrasonic 2D-frames throughout three cardiac cycles. The Pearson correlation coefficients and Bland-Altman analysis were performed to assess the relationship and agreement between IMT measured by the proposed and conventional manual methods.
    Results
    There was no significant difference between the proposed and manual methods with paired t-test analysis (in systole: 0.57 ± 0.10 vs. 0.56 ± 0.10 mm; P = 0.188 and in diastole: 0.63 ± 0.16 vs. 0.62 ± 0.10 mm; P = 0.122 for the manual and proposed methods, respectively). The Pearson correlation coefficients were r = 0.94 and r = 0.93 for IMTs and IMTd, respectively (both P < 0.001). Limit of agreements were narrow and considerable agreement was found between the two methods.
    Conclusions
    The present study demonstrated that the proposed computerized analyzing method can provide accurate measurements of the IMT of the CCA in sequential 2D ultrasonic images.
    Keywords: Carotid Intima, Media Thickness, Image Processing, Computer, Assisted, Ultrasonography, Cardiovascular Diseases}
  • Rebecca Luciana Russo, Stefano Zaffagnini *

    Videoinsight® means to gain insight by looking at a work of contemporary art. It focuses on the aim and the psychological effect that are potentially provoked by the interaction with some selected contemporary works of art. The insight promoted by the work of art is the outcome of the activation of transference, of projections and reflections on the artistic product, of the unconscious elaboration that leads to the development of transformation. Videoinsight® is a theoretical concept, a working method and a psychological process. It is based on the experience of exchange and integration between the contemporary artwork and the psychology of individuals who relate to it. Some works of contemporary art provoke and stimulate the psyche and activate psychological mechanisms. They trigger an intellectual and emotional experience: they make us think and feel a certain way. Interacting with selected works of art leads to the development and activation of human potentials. The Videoinsight® method can be applied in prevention, diagnosis, psychological support and psychotherapy for treatment of all psychological and psychosomatic diseases. It has been already applied in Medical Orthopedic Researches for rehabilitation and psychological support

    Keywords: Rehabilitation, Psychotherapy, Suicide, Art, Psychology, Assisted}
  • Ali Abbasian Ardakani, Akbar Gharbali, Afshin Mohammadi
    Background
    The aim of this study was to evaluate computer aided diagnosis (CAD) system with texture analysis (TA) to improve radiologists'' accuracy in identification of thyroid nodules as malignant or benign.
    Methods
    A total of 70 cases (26 benign and 44 malignant) were analyzed in this study. We extracted up to 270 statistical texture features as a descriptor for each selected region of interests (ROIs) in three normalization schemes (default, 3s and 1%-99%). Then features by the lowest probability of classification error and average correlation coefficients (POE+ACC), and Fisher coefficient (Fisher) eliminated to 10 best and most effective features. These features were analyzed under standard and nonstandard states. For TA of the thyroid nodules, Principle Component Analysis (PCA), Linear Discriminant Analysis (LDA) and Non-Linear Discriminant Analysis (NDA) were applied. First Nearest-Neighbour (1-NN) classifier was performed for the features resulting from PCA and LDA. NDA features were classified by artificial neural network (A-NN). Receiver operating characteristic (ROC) curve analysis was used for examining the performance of TA methods.
    Results
    The best results were driven in 1-99% normalization with features extracted by POE+ACC algorithm and analyzed by NDA with the area under the ROC curve (Az) of 0.9722 which correspond to sensitivity of 94.45%, specificity of 100%, and accuracy of 97.14%.
    Conclusion
    Our results indicate that TA is a reliable method, can provide useful information help radiologist in detection and classification of benign and malignant thyroid nodules.
    Keywords: ultrasonography, thyroid nodule, Diagnosis, Computer, Assisted, Artificial Intelligence}
  • رباب لطیف نژاد رودسری، فاطمه هادی زاده طلاساز *، معصومه سیمبر، نیره خادم غائبی
    مقدمه

    زوجین متقاضی استفاده از روش های اهدایی کمک باروری، در طی درمان با چالش های پیچیده ای مواجه هستند که می تواند اثرات روانی مهمی بر زندگی آنان داشته باشد که یکی از آن چالش ها، تصمیم برای انتخاب یک اهداء کننده مناسب است. مطالعه حاضر با هدف فراهم نمودن توصیف عمیقی از تجربیات زوجین نابارور استفاده کننده از روش های اهدایی در ارتباط با انتخاب اهداء کننده انجام شد.

    روش کار

    این مطالعه کیفی از نوع تحلیل محتوا با نمونه گیری هدفمند از تیر ماه 1390 تا مرداد ماه 1391 بر روی 32 زوج نابارور و داوطلب استفاده از روش های اهدایی کمک باروری مراجعه کننده به مرکز ناباروری شهر مشهد انجام شد. افراد مورد مصاحبه عمیق و نیمه ساختار یافته قرار گرفتند. تحلیل داده ها به روش تحلیل محتوای قراردادی انجام گرفت. برای تایید دقت و صحت داده ها از شیوه های بازنگری مشارکت کنندگان و استفاده از نظرات اساتید و همکاران استفاده شد.

    یافته ها

    تجربیات زوجین نابارور در ارتباط با انتخاب اهداء کننده در سه طبقه: چالش انتخاب نوع اهداء کننده، معیارگزینی در انتخاب و کنکاش تناسب اهداء کننده طبقه بندی شد. اکثر زوجین با اهداء کننده غریبه موافق بوده و مهم ترین معیار آن ها جهت انتخاب، ویژگی های اخلاقی وی بود. با این حال به دلیل محدودیت تعداد اهداء کنندگان، اکثر زوجین بدون توجه به آن و بدون هیچ تحقیقی از اهداء کننده، به انتخاب وی پرداخته بودند.

    نتیجه گیری

    محدودیت اهداء کننده، از مهم ترین عواملی است که عملا در تصمیم گیری اکثر زوجین جهت انتخاب اهداء کننده تاثیر اساسی داشته و باعث صرف نظرکردن زوجین از نوع اهداء کننده و معیارهای انتخاب می گردد.

    کلید واژگان: انتخاب اهداء کننده, روش های کمک باروری, مطالعه کیفی, ناباروری}
    Robab Latifnejad Roudsari, Fatemeh Hadizadeh Talasaz, Masoumeh Simbar, Nayereh Khadem Ghaebi
    Introduction

    Couples seeking assisted reproductive donation procedures are faced with complex challenges throughout their treatment which can have important psychological impacts on their life. Selecting a suitable donor is one of the hardest decisions they will ever make. This study was done aimed to provide an in-depth description of the experiences of couples in relation to donor selection.

    Methods

    In this descriptive exploratory qualitative study 32 infertile couples who were candidate to use assisted reproductive donation procedures were purposefully selected from Montaserieh infertility center، Mashhad، Iran in 2012. Data were collected through conducting semi-structured interviews and analyzed using conventional content analysis. Member check and expert debriefing were used to enhance study rigor.

    Results

    The experiences of infertile couples in relation to donor selection were classified in three categories: challenging selection of type of donor، adopting selection criteria and searching for donor suitability. Most of the couples agreed with unknown donors. The most important criterion for donor selection from couples'' point of view was moral issues. Nevertheless، due to limited number of donors، in most cases couples did not search about donor before selection.

    Conclusion

    Limited number of donors is the most important issue in most of couples to make decision regarding donor selection، which caused they relinquish from thinking on the type of donor and selection criteria.

    Keywords: Donor Selection, Infertility, Oocyte Donation, Qualitative Research, Reproductive Techniques, Assisted}
  • فریبا شکیبا، منوچهر ازخوش، بهروز دولتشاهی، سید جلال یونسی، مریم افتخار
    مقدمه
    امروزه با پیشرفت علم پزشکی، امکان باروری برای بسیاری از زوجین فراهم شده است ولی با توجه به ویژگی های این روش های درمانی و چالش های پیش روی آن، پذیرش آنها به عوامل متعددی بستگی دارد. لذا مطالعه حاضر با هدف تعیین رابطه بین ویژگی های جمعیت شناختی افراد نابارور با نگرش آن ها نسبت به روش های نوین کمک باروری انجام شد.
    روش کار
    این مطالعه همبستگی توصیفی در تابستان سال 1391 بر روی 250 زن و مرد نابارور مراجعه کننده به مرکز تحقیقاتی درمانی ناباروری استان یزد انجام شد. افراد به روش نمونه گیری تصادفی ساده انتخاب شدند. اطلاعات توسط پرسشنامه دو قسمتی که حاوی مشخصات فردی و عبارات نگرشی بود، گردآوری شد. داده ها با استفاده از نرم افزار آماری SPSS (نسخه 18) و آزمون های تی مستقل، آنوا و ضریب همبستگی پیرسون مورد تجزیه و تحلیل قرار گرفت. میزان p کمتر از 05/0 معنی دار در نظر گرفته شد.
    یافته ها
    بین طول مدت ازدواج (01/0=p)، مدت زمان ناباروری (001/0=p)، سن (04/0=p) و میزان درآمد ماهیانه (004/0=p) با نگرش افراد نسبت به روش های کمک باروری نوین ارتباط آماری معنی داری وجود داشت، ولی بین جنسیت، سطح تحصیلات و نوع سکونت با نگرش افراد نسبت به روش های کمک باروری تفاوت معنی داری وجود نداشت (05/0
    نتیجه گیری
    طولانی شدن مدت زمان ازدواج، مدت زمان ناباروری، افزایش سن و وضعیت اقتصادی مناسب، نگرش زنان و مردان نابارور نسبت به روش های کمک باروری را تحت تاثیر قرار می دهد.
    کلید واژگان: جمعیت شناختی, روش های کمک باروری, ناباروری, نگرش}
    Fariba Shakiba, Manoochehr Azkhosh, Behrooz Dolatshahee, Jalal Younesi, Maryam Eftekhar
    Introduction
    Nowadays، with advances in medical sciences، possibility of fertility has been provided for many couples، but according to characteristics of this methods and challenges facing these therapies، their acceptance will depend on several factors. The aim of this study was determining the relationship between demographic characteristics of infertile cases with their attitudes toward modern assisted reproductive techniques.
    Methods
    This descriptive-correlational study was carried out on 250 infertile men and women who referred to infertility research center of Yazd، Iran، 2012. Cases were selected randomly. Data were collected by two-part questionnaire containing demographic information and attitudinal statements and analyzed using SPSS software version 18، independent t-test، ANOVA and Spearman correlation coefficient tests. P value less than 0. 05 was considered significant.
    Results
    The differences between duration of marriage (p=0. 01)، duration of infertility (p=0. 000)، age (p=0. 04) and income (p=0. 004) were statistically significant with attitudes toward assisted reproductive techniques. But، no significant differences were found between attitudes scores toward assisted reproductive techniques and gender، education level and type of accommodation (p>0. 05).
    Conclusions
    The increase in duration of marriage، duration of infertility، age and adequate income will affect infertile attitudes toward assisted reproductive techniques.
    Keywords: Attitude, Demographic Characteristics, Infertility, Reproductive Techniques, Assisted}
  • راضیه دهقانی فیروزآبادی، عباس افلاطونیان، رباب داور، لیلی سخاوت، فاطمه منصوری مقدم
    مقدمه
    یکی از مراحل مهم در موفقیت تکنیک های کمک باروری، تحریک موثر فولیکول های تخمدان و القاء مناسب تخمک گذاری می باشد. مطالعه حاضر با هدف بررسی اثر استفاده از روش hCG با دوز کم به اضافه آگونیست هورمون آزاد کننده گنادوتروپین (GnRH) بر روی القاء تخمک گذاری و مقایسه آن با روش hCG تنها با دوز استاندارد در تکنیک IUI با پروتکل آنتاگونیست انجام شد.
    روش کار
    این مطالعه کارآزمایی بالینی در سال 91-1390 بر روی 100 زوج نابارور مراجعه کننده به مرکز تحقیقات ناباروری دانشگاه علوم پزشکی شهید صدوقی یزد انجام شد. زنان نابارور 18 تا 35 ساله که تحت درمان با پروتکل آنتاگونیست قرار گرفته بودند، پس از رسیدن حداقل 3 فولیکول به 18 میلی متر، به طور تصادفی به دو گروه مساوی تقسیم شدند. به یک گروه، hCG با دوز کم (2500 واحد) به اضافه آگونیست GnRH (2/0 میلی گرم تریپتورلین) و به گروه بعدی hCG تنها (10000 واحد) به صورت عضلانی تزریق شد. در هر دو گروه، 36-34 ساعت پس از تزریق، IUI انجام شد. داده ها پس از گردآوری با استفاده از نرم افزار آماری SPSS (نسخه 5/11) و آزمون های کای اسکوئر و تی دانشجویی مورد تجزیه و تحلیل قرار گرفت. میزان p کمتر از 05/0 معنی دار در نظر گرفته شد.
    یافته ها
    بیماران از نظر ضخامت آندومتر، میزان استرادیول در روز تزریق hCG و تعداد آمپول های گنادوتروپین مصرف شده تفاوتی نداشتند (1/0=p). سندرم تخمدان تحریک شده در گروه hCG تنها، بیشتر بروز کرد ولی این اختلاف از نظر آماری معنی دار نبود (1/0=p). بارداری شیمیایی در گروه آگونیست GnRH بالاتر بود (03/0=p)، و دو گروه از نظر بارداری کلینیکی اختلاف معناداری نداشتند (07/0=p).
    نتیجه گیری
    روش hCG با دوز کم به اضافه اگونیست GnRH، می تواند یک روش خوب و حتی جایگزین روش های استاندارد HCG در تحریک تخمک گذاری در پروتکل های آنتاگونیست محسوب شود.
    کلید واژگان: تحریک تخمک گذاری, تکنیک های کمک باروری, گنادوتروپین جفتی, هورمون آزاد کننده گنادوتروپین}
    Razieh Dehghani Firouzabadi, Abbas Aflatoonian, Robab Davar, Leily Sekhavat, Fatemeh Mansouri Moghadam
    Introduction
    One of the most important steps in success of assisted reproductive techniques is appropriate ovulation induction and effective ovarian follicles stimulation. The aim of this study was to investigate the comparison of low-dose hCG plus gonadotropin releasing hormone (GnRH) agonist on ovulation induction and with standard dose hCG alone in intrauterine insemination technique with antagonist protocol.
    Methods
    This clinical trial was conducted on 100 infertile couples who referred to infertility research center in Shahid Sadoughi university of medical sciences، Yazd، 2010 - 2011. Infertile women aged 18 to 35 who were treated with antagonist protocol were divided randomly into two groups after development of at least 3 follicles beyond 18mm diameter. Low dose of hCG (2500 IU) plus GnRH agonist (0. 2mg Triptorelin، intra muscular) were given to one group (n=70) and the next group (n=70) received hCG alone (10،000 IU، intra muscular). After 34 to 36 hours of injection intrauterine insemination was done in both groups. Data were analyzed with SPSS software version 11. 5 and T student and Chi-square tests. P value less than 0. 05 was considered significant.
    Result
    The patients were not different in terms of endometrial thickness، estradiol levels on day of hCG injection and the number of used gonadotropin ampoules (p=0. 1). Higher incidence of ovarian hyperstimulation syndrome (OHSS) was seen in the only hCG group، but this difference was not statistically significant (p=0. 1). Chemical pregnancy was significantly higher in low dose of hCG plus GnRH agonist (p=0. 03). However، no differences were observed between two groups in terms of clinical pregnancy (p=0. 07).
    Conclusions
    Using low dose hCG plus GnRH agonist can be considered as an appropriate and alternative method instead of standard methods of hCG in ovulation induction with antagonist protocols.
    Keywords: Chorionic Gonadotropin, Gonadotropin releasing hormone, Ovulation induction, Reproductive techniques, assisted}
نکته
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