جستجوی مقالات مرتبط با کلیدواژه « fluid » در نشریات گروه « پزشکی »

Considering the importance of early diagnosis of diseases as a challenge in medicine, which can be significantly effective in increasing the health level of society via preventing the progress and spread of infectious diseases, especially in developing and underprivileged countries with insufficient medical facilities. On the other hand, medical diagnosis methods that require advanced equipment and tools with expert staff limit the use of these tests. Along with the continuous development of technology, microfluidic systems have shown great potential to advance biomedical research that was previously unattainable using conventional techniques. For point-of-care applications, these systems can quickly detect diseases at low cost. This study discusses the challenges in the field of medical diagnosis and the importance of microfluidic systems as the best candidate to answer this need. Also, it describes the components of the microfluidic system, their manufacturing methods, and some of their most important applications in the field of health.

Carbamazepine (CBZ) is a BCS II class drug, having many challenges in solubility, flowability, and compactibility. The study focused on the improvement of solubility, flow behavior, and drug release of carbamazepine.

Low shear granulation (LSG), extrusion spheronization (ES), high shear granulation (HSG), fluid bed granulation (FBG), and hot melt granulation (HMG) methods were employed to prepare CBZ granules. Polyvinylpyrrolidone (PVP) K29/32, PVP K90, and Hydroxypropyl methylcellulose (HPMC) E5 were used as a binder. The drug to binder ratio was maintained in the proportion of 95:5. The nature of granules was analyzed by using X-ray Diffraction and Differential Scanning Calorimetry techniques. A powder flow tester was utilized to study the flow characteristics of the granules.

The HMG has successfully converted the crystalline structure of CBZ granules into an amorphous form. Dispersive and distributive mixing in the HMG has achieved better solid dispersion and fast drug release. The ES technique has reported the incompressible nature of the granules. PVP K90 and HPMC E5 were superior binders for imparting strength to the CBZ granules than PVP K29/32. The FBG has exhibited the free-flowing nature of granules due to their uniform and spherical shape.

The HMG and FBG were the most effective methods that have remarkably improved drug release, flow properties, and compactibility of CBZ granules.

Functio nal Gastrointestinal Diseases ( FGIDs ) impose a huge health burden , and lead to metabolic and mental disorders, impaired social function and productivity, reduced quality of life, higher total mortality and health care cost . Beverages are one of the major c omponents of habitual dietary habits that may influence the symptoms of FGIDs.

The purpose of this study was to review the effect of frequent dietary fluids on common causes of FGIDS including functional dyspepsia (FD), irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD) and functional constipation (FC) .

A literature search was done using the following search engine s : PubMed, Google S cholar and ISI web of science with the following search terms “beverage s ”, tea”, “caff eine”, “coffee”, “milk”, “water”, “fruit juice”, “carbonated beverage”, “constipation”, “irritable bowel syndrome”, “gastroesophageal reflux disease”, “dyspepsia”,.

In this review, 85 studies were evaluated . It was shown that to higher intakes of caffeinated drinks, fruit juice, milk, soft drinks and carbonated beverages a re associated with aggravating symptoms in GERD, IBS and FD. The data on the relation between water consumption with GERD, IBS and FD a re limited and inconsistent. However, consu mption of fruit juices and water was related to an improvement in constipation.

Fluid intake can be effective in the management of FGIDs symptoms. However, further investigation on the role of various fluids consumption on symptoms of FGIDS is required