جستجوی مقالات مرتبط با کلیدواژه « premature neonate » در نشریات گروه « پزشکی »

Due to the possible complications of a persistent ductus arteriosus (PDA), the treatment of the PDA will be necessary, depending on the opinion of the treating physician. Medical or surgical treatment can be used in this regard. In recent years, acetaminophen has been considered a medication with fewer potential side effects.  The present study aimed to compare acetaminophen with ibuprofen in the patent ductus arteriosus in neonates admitted to training hospitals in Khorramabad.

A total of 28 neonates were included in this retrospective cohort study. The required data were collected by studying the patients' files. The PDA in newborns was diagnosed by primary echocardiography by the attending physician. Thereafter, 12 and 16 cases were treated with ibuprofen and acetaminophen, respectively. After completing the treatment period on days 3 and 5, the attending physician performed echocardiography to check PDA closure. Data were analyzed in SPSS software (version 24) using descriptive indices of mean, standard deviation, frequency, percentage, Fisher's exact test, and Mann-Whitney U test.

In this study, the frequency of affected male neonates was the same as that of affected female newborns (n=14; 50%). The mean weight scores of neonates in acetaminophen and ibuprofen groups were obtained at 2831/25±918/49 and 2241/5 ±868/9 gr, respectively. All newborns in both groups were treated; thereafter, 23 cases recovered with 3-day treatment and 5 neonates with 5-day treatment. No significant complications were observed in patients.

The effect of acetaminophen on PDA closure was similar to that of ibuprofen. The need for 5-day treatment was higher in the acetaminophen group; nonetheless, no significant side effects were reported in any newborn. According to this study, acetaminophen can be a good alternative to ibuprofen in the treatment of PDA.

Pain causes mental-psychological injuries in babies by affecting neuronal development. This study was conducted to evaluate effect of music therapy and Swaddling on physiological indicators and pain intensity caused by blood sampling in preterm neonates.

Method and Materials:

 This randomized controlled clinical trial was performed on 51 preterm neonates admitted to NICU of Persian Gulf Hospital in Bushehr. The newborns were divided into music, swaddling and control groups by random block allocation method. For neonates in music therapy group, music was played from 5 minutes before to two minutes after blood sampling, while neonates in swaddling group were swaddled with a thin sheet from 10 minutes before blood sampling to two minutes after. In all groups, HR and o2sat were measured 30 seconds before, during, 30, 60, 90, 120 seconds after blood sampling. Also, from 30 second before blood sampling to 2 minutes after, neonates' faces were filmed and pain assessment checklist was completed each 30 seconds. Data analyzed using Kruskall Wallis H and ordinal regression tests.

There was a significant difference between pain score in intervention groups, so that pain score in Swaddling group was lower than music group at 90 and 120 seconds. In intervention groups, HR changes were lower than control group. No significant difference was observed between three groups regarding o2 saturation.

Results showed that swaddling and music therapy can reduce pain caused by blood sampling and keep vital signs more stable, but swaddling has a greater effect on reducing pain in newborns.

Many care and treatment approaches in the NICU are accompanied by pain as a recurrent complication during neonates’ hospitalization. The performance of a nurse as an important member of the care team can directly affect pain management.The aim of this study was to determine the effect of training on neonatal intensive care nurses’ performance regarding pain management in premature neonates.

This is a quasi-experimental study including two groups which was performed through a pre-post comparison .The nurses in the intervention group participated in three sessions of theoretical and two sessions of practical training. The tool for evaluating nurses’ performance regarding pain management in premature infants was completed by the nurses in both groups on three occasions including before training, one week after the training, and three weeks after it. The data was analyzed using SPSS V25 with a significance level of 0.05.

The nurses’ demographic information including age, education, working shift, work experience, and the type of employment were not significantly different in the two groups.There was a significant difference in mean scores of the nurses’ performance between the intervention and the control groups one week and three weeks after the intervention(P-value < 0.001).In addition, the mean score of the nurses’ performance in the intervention group one week and three weeks after training was significantly different (P-value < 0.001).

Holding theoretical and practical workshops can affect nurses’ performance in regard with pain management in premature Neonates in the NICUs.

Due to the prevalence of myocardial dysfunction and Patent Ductus Arteriosus (PDA) in a large number of preterm neonates, the prognosis of these infants is highly related to their early diagnosis and treatment. In this regard, the present study aimed to determine the relationship between troponin T level and the prognosis of premature neonates admitted to the Neonatal Intensive Care Unit (NICU) of Fatemieh Hospital in Hamadan.

In this cross-sectional study, a certain number of infants who underwent serum levels of troponin T from 72 hours to one week after birth were assessed for demographic information, length of hospital stay, complications during hospitalization, acidosis, inotropic agents, recovery, and mortality, as well as their relationship with troponin level.

Out of 61 neonates, 22 patients had large PDA with a troponin level of 436±50.2 pg/ml, 14 patients had a small PDA with a troponin level of 260.5±89.8 pg/ml, and 25 patients were without PDA with a troponin level of 277.1±229.7 pg /ml (P = 0.203). There was no statistically significant difference between the three groups. The mean levels of troponin were 423±521 and 274±154 pg/ml in deceased and surviving neonates, respectively (P=0.194). Inotropic was significantly higher in deceased patients (P=0.003), and troponin T level was statistically significant (P=0.008). The relationship between troponin level and severe acidosis (P=0.051) was not significant, with a small difference that could be clinically valuable.

Serum troponin T level was higher in preterm neonates with large PDA and deceased ones who received inotropic agents due to hemodynamic disorders and severe acidosis.

Gavage feeding tubes increase the length of stay and reduce the growth process in neonates. The aim of this study was to determine the effect of non-nutritive sucking on weight gain and length of stay in neonates that required gavage feeding.

In a clinical trial, neonates were selected via convenience sampling and randomly assigned into an intervention group (n=37) or a control group (n=38). Data including demographic information, admission and discharge dates, and neonates’ weights were recorded. In the intervention group, non- nutritive sucking was performed by the mother's finger at the same time as the gavage feeding. Data analysis was performed in SPSS V20 applying independent t-test, Mann-Whitney, and Chi-square.

The mean weight at discharge was 90.73 g higher in the intervention group than the control group (P=0.121). The mean weight loss was found to be higher in control group than the intervention group (P= 0.818). The mean length of stay was 14.22± 8.32 days in intervention group and 14.61±7.34 in control group, indicating no significant differences between the two groups (P=0.830, statistical power=60%).

Non-nutritive sucking had no significant positive effect on length of stay and weight gain in preterm infants. Further studies with larger sample size are suggested.

The association of maternal vitamin D status with preterm labor has been considered in the recent decade, although reported findings have been inconsistent. This study was performed aimed to compare serum 25-hydroxy vitamin D levels between women with idiopathic preterm labor and women with term labor.

This case-control study was performed in 2020 on 60 women aged 18-35 years who had referred to Bentolhoda Hospital in Bojnourd for delivery. Serum levels of 25-hydroxyvitamin D were determined in 30 women with idiopathic preterm delivery with gestational age of 28 to 37 weeks (case group) and 30 women with term delivery (control group) by sandwich ELISA. Patients' information including demographic information, clinical status and pregnancy history were collected through a questionnaire. Data were analyzed by SPSS 16 software (version 16) and Chi-square and Pearson correlation coefficient test. P<0.05 was considered statistically significant.

About fifty-six (93.4%) of the participating mothers had some degree of vitamin D deficiency. Previous history of abortion, still birth and previous preterm labor were not associated with preterm labor, but primigravida increase the risk of preterm labor up to 8 times. The mean 25 (OH) D in women with preterm labor was higher than control group (19.8±8.9 vs. 14.52 ± 5.4 ng/ml, P = 0.007).

Although serum vitamin D level in mothers with preterm labor was significantly higher than those with term labor, but due to the limitations of this study, we cannot rule out the possibility of vitamin D deficiency as a risk factor for preterm labor.