جستجوی مقالات مرتبط با کلیدواژه « uropathogen » در نشریات گروه « پزشکی »

Escherichia coli (E. coli) are known to be a major cause of uropathogen among women globally. Urinary tract infection in pregnant women continues to pose clinical problems, which is a big burden for physicians. The emergence of antibiotic resistance to E. coli is inevitable and one of the critical health-associated problems. The present study aimed to determine the E. coli isolates, risk factors, and antibiotic resistance profile of the UTI among pregnant women.

We conducted this cross-sectional study on pregnant women who attended maternity hospital in Zakho City, Kurdistan Region, Iraq. From October 2020 to January 2021, 196 subjects were recruited in the present experiment. Uropathogenic E. coli were detected from mid-stream urine of the participants. Subsequently, we performed antibiotic sensitivity test using microbiological standard tests. Through the use of designed questionnaires, the required data were collected, processed, and analysed via the Fisher’s exact test and Chi-square.

Out of a total of 196 subjects, 34 (17.34%) were culture positive for E. coli infection among pregnant women. A high rate of infection was detected in the age group of between 25-34 years (21.6%). Additionally, the highest rate of E. coli belonged to illiterate people (19.4%), followed by those with higher education (18.9%). The assessment of the risk factors associated with E. coli indicated that diabetes (P=0.028), a history of UTI infection (P=0.049), and the presence of symptoms during infection (P=0.001) were statistically significantly different. The antibiotics sensitivity profile in urine samples of pregnant women showed that E. coli were extremely sensitive to Nitrofurantoin (82.4%), Meropenem (79.4%), and around 67.6% for both Amikacin and Ciprofloxacin.

The prevalence rate of E. coli infection is quite lower among pregnant women compared to that in non-pregnant ones. The major risk factors associated with E. coli during pregnancy were diabetes mellitus, a history of UTI, and the presence of symptoms during infection. E. coli isolated from urine samples seem to be different concerning antibiotic sensitivity pattern. During their regular follow-up, pregnant women should also be examined for major risk factors and antibiotic susceptibility.

One of the most common diseases worldwide is urinary tract infection (UTI). The main agents causing these infections are bacteria. Urinary tract infections occur when uropathogens colonize the urethra, migrate to the bladder and invade urinary tract cells.
The purpose of this study was the detection of uropathogens causing UTIs, as well as serotyping and antibiotic susceptibility of the most common bacteria.
The study was performed on 300 urine samples collected from patients referred to Koohdasht Imam Khomeini hospital of Lorestan province. After culturing the samples and determination of uropathogens, antibiotic susceptibility test was performed by the Kirby-Bauer disk diffusion method. Serotyping was performed for the most common uropathogens by polyvalent and monovalent antisera.
Of the 300 samples, 61 samples (20.33%) were positive for UTIs. Among these, 49 samples (80.33%) were Gram-negative bacteria and 12 (19.67%) Gram-positive. The most common uropathogens in UTIs were Escherichia coli (55.74%), Proteus species (11.47%), Staphylococcus epidermidis (11.47%), Citrobacter species (8.20%), Staphylococcus aureus (8.20%) and Klebsiella species (4.92%), respectively. The rate of UTI in females (83.61%) was more than males (16.39%). The highest level of resistance was towards trimethoprim/sulfamethoxazole and the lowest to ampicillin, ciprofloxacin and nitrofurantoin. The most common uropathogen was Escherichia coli and the most common serotypes were O142:K86 and O25:K11, respectively.
The treatment of UTIs and resistance control in bacteria should be done based on common strains and choosing an effective antibiotic. Therefore, the determination of prevalent bacterial strains in UTIs of each region based on laboratory tests is very important.