جستجوی مقالات مرتبط با کلیدواژه « zinc sulphate » در نشریات گروه « پزشکی »

Exposure to excessive sound leads to hearing loss. Temporary threshold shifts are defined as threshold shifts that return to baseline levels in the hours to weeks after excessive sound exposure.

This study aimed to examine the zinc sulfate protective effect following noise exposure.

Fifty-two participants with normal audiograms at baseline were randomly assigned to control and intervention groups. First, a distortion product otoacoustic emission test (DPOAEs) was carried out as the baseline assessment, then the intervention group received zinc sulfate supplement capsules for one month and placebo capsules were given to controls. To induce a transient hearing shift, an ABR test was performed. The ABR test was done with 90 dB of soundstimuli for each ear. This input stimulus was a noise exposure that induces a temporary reduction in hearing, in fact, a transient hearing shift has occurred. Then, both groups had a DPOAE test anda follow-up assessment. Signal/noise ratio and DP (distortion product) levels were measured to evaluate the effect of zinc supplement use on transient hearing shift.

Comparing the results of the distortion product otoacoustic emission test before and after the auditory brainstem response testing showed significant differences between intervention and control groups (p<0.05). Moreover, the differences in signal/noise ratio between the intervention group before and after ABR testing and also in the control group were significant (p<0.05).

Dailyzinc sulfate supplement might protect against thetransient hearing shift.

The aim of this study is to find out the prevalence of hypozincemia in patients suffering from Tinnitusand to investigate the effect of Zinc therapy upon the severity of Tinnitus. Patients and We studied 66 who suffered from tinnitus, which were randomized to two groups according to the zinc level including < 50 μg /dl and > 50 μg /dl groups. The zinc level was measured in non-diluted serum by flame atomic absorption spectrophotometry from fasting blood samples. The zinc level in< 50 μg /dl and > 50 μg /dl groups, before and after treatment (47.750 vs. 77.3 μg/dl, P < 0.02; 86.6 μg/dl vs. 98.2 50 μg /dl, P<0.001, respectively) was statistically significant. Hence, in Placebo group, before and after treatment the zinc level was not statistically significant (73.2 μg/dl vs.72.6 μg/dl, respectively). The result showed that the mean of subjective tinnitus in zinc group decreased. However, the decrease in severity of the tinnitus was not significant in patients receiving placebo. The zinc level increased significantly in the patients treated with zinc.This study indicate that administration of zinc has a beneficial effect on tinnitus but these results still have to be confirmed in clinical trials with larger samples.

Cutaneous leishmaniasis (CL) is an endemic disease in developing countries. Although pentamidine orantimonite (Glucantime) has been recommended for cutaneous leishmaniasis treatment by the World Health Organization, there are some concerns too such as high cost, side effects, need for frequent injections, and restricted efficacy. Therefore, different methods have been used for CL treatment so far.. This study assessed the sensitivity of two parasite agents of cutaneous leishmaniasis: Leishmania major and L. tropica to zinc sulphate in vitro. In the present study, the zinc sulphate effect on urban and rural strains of cutaneous leishmaniasis, viability of old world, in vitro is under investigation.. The design of the present study was experimental (laboratory-trial) based. Iranian endemic species of L. major and L. tropica were appropriately collected, proliferated, and maintained in the standard culture. Afterward, the proper concentrations of zinc sulphate were provided, sterilized, and added to the cultures containing parasites. In different intervals, parasites were counted by two the slide and cell proliferation ELISA.. Both parasite species showed sensitivity to zinc sulphate in vitro and in comparison with the control group, their numbers were reduced. Zinc sulphate (in concentrations of 0.5, 1, 2, and 3percent) was added to the cultures containing parasites, and the total number of the live parasites was counted through the slide method (Neubauer slide) every day up to the fifth day. The results were analyzed and found statistically significant (P < 0.05). In the second phase, the counting process was repeated with the addition of zinc sulphate compound with different concentrations (3, 4, 5, and 6 percent) and live parasite numbers were counted by ELISA method after 24 hours. The findings revealed that all the cultures containing zinc sulphate showed a slower growth in comparison to the control group. The mentioned difference was statistically significant (P < 0.05)... Considering the safety of zinc sulphate compound in comparison with Glucantime, there is a possibility of using it in the treatment of CL caused by both species of L. major and L. tropica. It is obvious that more researches are mandatory both in vivo and in vitro to figure out its daily dosage, proper concentration, time and duration, and possible side effects..