جستجوی مقالات مرتبط با کلیدواژه "antifungal effects" در نشریات گروه "دامپزشکی"

Based on the historical and recently published documents, it has been demonstrated that Mirabilis jalapa as a herbal medicine may be used as remedies for various health problems included wound healing purposes.

The present study aimed to investigate the effect of ethanolic extract of Laleh abbasi green leaf on healing open wounds induced by skin puncture in the back of rats.

Collecting and drying Laleh abbasi leaves, leaf extracting through Soxhlet procedure, analyzing the extract via gc / ms method, and preparing eucerin-based extract ointment were done according to recommended routine procedures. Herein, we recruited 40 male rats that were randomly divided into five groups of eight, namely the control, phenytoin treatment, eucerin, 5% eucerin extract, and 7.5% eucerin extract ointment treatment groups. Skin puncture and application of ointments on the induced wounds were carried out. Subsequently, tissue samples were taken on days 3, 7, 10, and 14, followed by which histological slides were prepared and stained with H&E and Masson’s trichrome staining methods. In vitro mycological studies were conducted using opportunistic fungi, including Candida, Mucor, and Aspergillus species.

Based on the macroscopic evaluations of the wound healing process and microscopic assessments of tissue samples stained with Harris H&E and Masson’s trichrome methods, the groups treated with eucerin-based ointments containing ethanolic extract of Laleh abbasi leaf had statistically significant positive wound healing responses compared to the other groups. However, the 7.5% ointment group showed statistically better responses compared to the 5% ointment group. The data obtained in the present preliminary experiment on rat model indicated that the extract could facilitate the wound healing process in terms of healing parameters, such as accelerating epithelium repair, creating a favorable inflammatory reaction, angiogenesis, fibroplasia, and collagen precipitation. The antifungal effects of ethanolic extract of Laleh abbasi leaves on Aspergillus fumigatos, fusarium, Candida albicans and Candida cruzei were demonstrated in vitro using saboro dextrose agar medium.

According to the findings of this experimental study and the findings of other researchers, it can be concluded that ethanolic extract from Laleh abbasi leaves is of healing and antifungal properties.

Dangers of synthetic drugs and synthetic food preservatives, increased bacterial infections resistance to antibiotics, Due to the important fungal diseases Such as aspergillosis and Mycotoxicosis, and also mold decay of agricultural products and the capacity of essential oils against microorganisms has provided fertile ground for research. To this end, antifungal activity of essential oils of three herbs Cuminum cyminum, Zataria multiflora Boisis, and Eugenia caryophyllata, Compared with the formalin on the growth Aspergillus parasiticus was studied. To determine the minimum inhibitory concentration of essential oils and mean diameter of fungal growth, and the percentage inhibition of essential oils, poisoning solid medium was used. The results showed that essential oils tested, have Inhibitory effect at all concentrations and ability to inhibit the growth of fungal oils was more than chemical fungicides (formalin). The highest and lowest diameter of fungal growth for concentrations 125 μl/l after 8 days of incubation was associated with formalin and Eugenia caryophyllata respectively 62.8 and 14.1 mm. Eugenia caryophyllata and Cuminum cyminum essential oils with concentration of 250 μl/l and Zataria multiflora Boisis essential oil and formalin with concentration of 500 μl/l were able to inhibit completely the growth of Aspergillus parasiticus. So the essences of Eugenia caryophyllata and Cuminum cyminum with a high percentage of inhibitor, respectively, as the best essential oils for controlling the growth of Aspergillus parasiticus instead of chemical fungicides, recommended.