جستجوی مقالات مرتبط با کلیدواژه « Albendazole » در نشریات گروه « دامپزشکی »

During the last two decades, anthelmintic drugs have been increasingly applied against gastrointestinal parasites of sheep in Iran.

For this purpose, drug resistance to albendazole (Alb) and fenbendazole (Feb) in gastrointestinal nematodes in sheep of Saqez multiplicity was assessed.

In in-vivo experiment, a total number of 90 sheep in three groups (30 sheep/group) with EPG≤150 were examined for nematode resistance to Alb and Feb. They were treated with Alb and Feb or untreated (as a control group).

There was significant difference between Alb and Feb treated groups and control group. The EPG in Alb, Feb and control groups was 59.8±1.93, 18.8±1.258 and 204.07±4.81, respectively. There was drug resistance against Alb in compassion with control group (R=71%). There was suspicion drug resistance for Feb in comparison with control group (R=90.66%).

From the results of the present study, it was concluded that there was absolute and suspected drug resistance against Alb and Feb in sheep of Saqez municipality, Iran, respectively.

Helminths with creation of clinical diseases, some mortality and subclinica l Complications such as weight loss and anaemia caused a sharp drop in livestock production. Therefore, fighting with them especially in the sheep, which are highly dependent on pasture and therefore are susceptible to worm infection have been considered by veterinary organization so long before and drugs such as albendazole and levamisole have been used in abundance in Iran. In present study, in order to determine the effectiveness of two drugs; albendazole and levamisole, three groups comprised of ten sheep in each group had been chosen in five flocks near the city of mashhad, and after making sure of their physical health, in two stages, one just before administration of the drugs and the other 14 days later, faecal samples were taken from all studied sheep. Then, albendazole (7.5mg/kg) and levamisole (7.5mg/kg) were given to the group one and two orally, respectively. No drug was administrated to the group three as the control group. Counting of parasite eggs in faces (EPG) were performed by using Clayton-Lane method and efficacy of anthelminthic drugs were evaluated by egg reduction rate formula. The results showed that average efficacy of albendazole and levamisole were 46% and 44% respectively which should be considered. So, providing proper instruction under consideration by the aim and time of drug administration, type of parasite, infection rate of worms, the appropriate dosage according to animal species in order to prevent or delay the development of resistance is necessary.