Evaluation of the anti- depressant activity of Myristica fragrans (Nutmeg) in male rats

The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Our study demonstrated the potential antidepressant activity of MS.