Survey of effectiveness of intrathecal administration of combination of sufentanil and morphine for postoperative pain relief after laparatomy

There are many methods to provide pain relief after operation، that includes: IV or IM opioids injections، patient controledl analgesia، uses NSAIDs useing (IM، IV or rectal). All of these methods have advantages and disadvantages. Another techniques for post operative analgesia is epidural catheter insertion and administration of opioids or local anesthetic continously. The goal of this study is to compare intrathecal administration of combination of sufentanil and morphine for postoperative pain relief after laparatomy. 40 ASA I-III patients who were candidates for laparatomic surgeries enrolled in two groups in this clinical trial study after written inform consent (randomly assigned). One group (N=20) before general anesthesia received a spinal injection of Sufentanil (5μ) and morphine (0. 3mg) (S-M groups) and another group (control group) didn''t receive intrathecal opioids. Post-operative pain was rated on a visual analogue scale (VAS) at rest in 6 and 12 hours after operation and also total dose of injected morphine for 24 hours after operation calculated. The data were analyzed by SPSS16، T-test، Chi-Square and paired T-test. Intrathecal injection of sufentanil and morphine caused VAS scores at rest were ignificantly higher in the control group in 6 and 12 hours after operation and total dose of morphine consumption was significantly lower in the SM group. Combination of intrathecal sufentanil and morphine produce good analgesic effect after laparatomic surgery at 12 hours after operation.