Silver nanoparticle induced muscle abnormalities: A sub-chronic dermal assessment in guinea pig

Nanosilver has recently been recognized as an antimicrobial agent. Although this nanoparticle can be used in medical applications but its dermal and systemic toxicity via dermal exposure has not been completely determined yet. The aim in this study was to investigate the potential ermal toxicity of Nanosilver in subchronic method. Before the colloidal silver nanoparticle toxicity evaluation, their size was subjected in sizes < 100 nm by Transmission Electron Microscope and revealed that the nanoparticles contained nanosilver by X-Ray Diffraction. The selected animals were 24 male guinea pigs weighing 350-400 g. These animals were exposed to three concentrations of nanosilver (100, 1000 and 10000 μg/ml) by dermal exposure. Toxic responses were assessed based on histopathologic parameters. Significant dose-dependent histopathological changes were observed in the muscle of treated animals. It seems that colloidal ilvernanoparticles have the ability to create dose-dependent toxic responses in this organ.