Study the relationship between Q192R paraoxonase gene polymorphism and high density lipoprotein composition after Lovastatin Trapy

Enzyme paraoxonase 1 (PON1) has the main antioxidant function of HDL. Statins affect PON1 concentration and expression، therefore the fatty acid composition of phospholipids in HDL is changed by statins. The aim of this study is to investigate the effect of Lovastatin on paraoxonase activity and HDL phospholipids composition in genotypes of Q192R polymorphism. In this descriptive analytical study، 265 participants from Kashani hospital were randomly divided into two groups. One hundred and thirty participants with LDL higher than 130mg/dl were chosen for case and 134 participants with LDL lower than 130mg/dl were chosen for control group. Considering the expert''s idea، the control group was divided into two groups. Group receiving Lovastatin (n=76) and another group receiving no treatment (n=55). From all participants the blood sample and glucose level، total cholesterol، thriglisirid، HDL، LDL، creatinine، apolipprotein A1، apolipoprotein B، OxLDL، PON1 arylesterase and paraoxonase activity were measured. Q192R polymorphism genotypes were determined using PCR-RFLP method. 2 months after Lovastatin treatment lipid profiles and paraoxonase activates and fatty acid components were measured. Data were analyzed using SPSS software. After using Lovastatin; paraoxonase activity، percentage of stearic acid، oleic acid، Linoleic acid and Eicosapantaenoic acid were increased before the treatment. The Q allele showed the same frequency in the control and case groups (0. 77 and 0. 70 respectively p=0. 24) Percentage of oleic، linoleic، Eicosapantaenoic acid and paraoxonase activity in QR / RR were higher than QQ genotype after the treatment. Based on the findings of this study in individuals with alleles R (QR/RR) increasing paraoxonase activity and changing unsaturated fatty acids of phospholipids HDL particles، results in changes the nature of these particles and may decrease cardio vascular disease.