The preventative role of sesame oil on phlebitis induced by anti-neoplastic agents

Phlebitis is an inflammatory response to intravenously injected chemotherapy drugs and thereported incidenceis about 70% among colorectal cancer patients. The purpose of this study wasto determine the effect of external use of Sesame Oil (SO) in prevention of chemotherapy-induced phlebitis. This randomized controlled clinical trial was performed on 60 patients with colon or rectum cancer, whorandomly divided in two equal, control & intervention groups.This protocol was used 10 drops of SO every 12 hours, two times a day, from the first day of chemotherapy up to the four teenth day, whereas control group received nothing. Data tools included a bipartite questionnaire (demographic Q, clinical Q & Infusion Therapy scale) for measurement of phlebitis. The incidence of phlebitis in intervention group were significantly lower than that in control group (p<0.05). Kaplan–Meier survival analysis showed that the median survival was Less than4 days in the intervention and 8 days more in the control. In addition, there was statistically significant difference between grade and incidence ofchemotherapy-induced phlebitis with SO and control group (p<0.05). This study shows that external use of SO is effectiveand well tolerated for prophylaxis from chemotherapy- induced phlebitis. Therefore, it can be suggest as a selected Prevention methodforreducingthecomplication.