Relationship between Serum Prostate-Specific Antigen (PSA) and Prostate Size and Also PSA and Body-Mass Index (BMI)

Defining the optimal prostate-specific antigen threshold to identify the patients at the highest risk of prostate cancer has always been controversial. This study aims to analyze the diagnostic value of PSA and also evaluate the relationship between PSA and BMI as well as PSA and prostate size in asymptomatic subjects referring to the Check- up Clinic of Razavi hospital. In this descriptive، cross- sectional and retrospective study; the demographic data as well as total PSA and also prostate size of 1149 subjects who had referred to the Check- up clinic of Razavi hospital during 2006 - 2011 were evaluated according to their Sonography reports. All the subjects were asymptomatic. Data were analyzed by SPSS as well as descriptive and statistical tests. The mean age of the subjects was 45 ± 12 and BMI was reported 27± 8. Very low and inverse correlation was determined between PSA and BMI. Non- significant correlation was reported (p ₌0. 08، r₌ 0. 054). It was also observed that the correlation between PSA and BMI was greater than the correlation between PSA and prostate size individually (p ₌0. 001، r₌ 0. 394). According to this study، although non- significant relationship was observed between PSA and BMI; but a significant relation had been reported in other studies which were carried out on the symptomatic subjects perviously. The mentioned significant relation may be the result of PSA> 10. So it can be doubted that in the high level of PSA these relationships could be validated.