Interactive Effect of Lead, Endurance Training and Curcumin Supplementation on some Reproductive Parameters

The purpose of this study was to investigate the interactive effects of lead, endurance running and curcumin antioxidant supplementation on some reproductive parameters in rats. 60 male Wistar rats were divided into six groups(10 rats/group): base, sham, lead, exercise + lead, curcumin + lead, exercise + curcumin + lead. The lead-treated and curcunin-treated group were exposed to lead acetate(20 mg/kg), curcumin (30 mg/kg) in peritoneally. The shamoperate group (sham); received water and ethyl oleate, in the same manner and for the same duration of time. aerobic training were performd for 8 weeks. Training protocol was performed, 5 days a week, with speed 15 to 22 meter per minute and duration of 25 to 64 minutes. Motility and morphological profile of sperm were assessed by standards methods. The testis and epididymal MDA were assessed by TBARS method. The data was analyzed using SPSS 16 statistical analysis software with α ≤ 0.05. results showed compared with other groups mean values of testis and epididymis lipid peroxidation was higher in lead-treated group but not significant. As well as lead administration was corrupted motility and morphology of sperm in lead-treated group, but intervention of endurance training and curcumin supplement have an ameliorating effect on this parameters. The results of this study shows that regular moderate endurance running and using curcumin supplement are suitable guideline to inhibit the negative effects of lead on reproductive system.