The Effects of Opium Addiction through Different Administration Routes on Inflammatory and Coagulation Factors

Based on an experimental trial, we tried to test the effects of opium addiction through different administration routes on inflammatory and Coagulation Factors. This study was performed on 30 adult male Syrian golden hamsters allocated to one of three groups: control group which received no opiate; the first study group received oral opiate; and another study group received inhaled opiate. After 4 weeks, all hamsters were anesthetized with diethyl ether and their blood samples were obtained from their hearts for laboratory assessment. The blood level of hs-CRP was significantly higher in group used opium orally compared with the group used opium orally (P < 0.001); other markers were not different between the two experiments groups. The level of hs-CRP was higher in the two study groups than the controls. Blood hemocysteine levels following oral and inhaled opium use were comparable with the controls. Our study confirms the triggering role of opiate dependence through different administration routes on inflammatory process, especially through its oral usage.