Antibacterial Effect of Ethanol Extract (Althaea Officinalis) on Streptococcus Pyogenes Compared with Prevalent Antibiotics In-Vitro

Streptococcus Pyogene s causes Impetigo، Scarlet fever and Angina. Marsh mallow (Althaea officinalis) is one of medicinal plants in old medicine that has been used for curing the above diseases. Due to health problems related to antibiotics such as drug resistance and disease relapse، this study was conducted to investigate antibacterial activity of ethanol marshmallow root extracts collected from different regions of Iran. In a laboratory study that was conducted in 2012، Roots of Althaea officinalis collected from regions Qom، Tehran، Yazd، Anar، Zarand، Esfahan، Arak، Naien، Mahan and Baft and then Extraction procedure was carried out by Maceration method with ethanol then Effect of Different extract concentrations and regions on bacterial growth were compared with one and two-way analysis of variance. Paired means comparison was performed using Duncan''s method and MIC of extracts was determined. Ethanol root extracts had antibacterial activity and inhibition zone had logarithmic response with increase of extract concentration. The highest inhibition zone was in concentration of 200 mg/ml and concentration of 50 mg/ml of yazd extract had same as Penicillin effect. The extract from Yazd region had Minimum of MIC with maximum of antibacterial activity and the extract of Tehran region had Minimum antibacterial activity and there wasn’t any activity from Arak extract. Results show the effect of extract concentration and region of plant growth on bacterial growth. Therefore، to achieve the best therapeutic effect these issues should be considered.