Comparison of antifungal activities of semipolar- nonpolar secondary metabolites of Ircinia mutans extracts in two different seasons from Kish Island, Persian Gulf

In this research for the first time tested antifungal activity of Ircinia mutans, collected from Kish Island in the Persian Gulf. The extracts were produced by Bligh & Dyer method, In vitro antifungal activity by Broth Dilution Methods against clinical pathogens Candida albicans ATCC10231 and Aspergillus fumigatus PTCC5009. The results conducted that the aqueous extracts didn’t have any antifungal activities on pathogens, minimum inhibitor concentrations (MIC) of the diethyletter extract was found on C. albicans and Aspergillus fumigatu, but MFC was not found. The MFC of summer and winter metanol extracts were 20mg/ml and 3mg/ml on A. fumigatus and 0.5 mg/ml and 1.5 mg/ml on C. albicans. Therefore secondary metabolites solutions in metanol, polar components have antifungal activity and it can be used for supplementary experiments to isolate and identify the fungicide active ingredient.