Effect of pentoxifylline administration on skin biomechanical indices in acute phase of skin wound healing in rat

Pentoxifylline is a xantin derivative that causes deduction of blood viscosity، improves peripheral blood current and increases tissues oxygenization. In this study، considering special properties of this drug and inspite of undefined mechanism of its effect، the effect of pentoxifylline on skin biomechanical indices in acute phase of skin wound healing in rat is evaluated. In this experimental study 14 adult Wistar rat were divided in two groups of experimental (n=7) receiving 100mg/kg twice a day and control (n=7) receiving distilled water intraperitoneal. Incisional wounds، 20mm length in identical pattern were created on back skin of rats. On day 15 skin strips containing incision were excised and used to evaluate biomechanical indices، work up to maximum force-Nm and Tensile strength= Rm-N/mm2. Results were analyzed by Spss soft ware and K-S، Levens and student T-Test. According to biomechanical test findings، pentoxifylline administration causes improvement in biomechanical indices of skin after 15 days of drug administration. Discrepancy between skin biomechanical indices of experimental and control subgroups was significant (p<0. 05). Pentoxifylline caused improvement in skin biomechanical indices and accelerated skin wound healing in experimentals.