The effect of glutamine supplementation on intensity of perceived pain and Creatine Kinase after eccentric contraction in untrained men

The purpose of this study was to investigate the effects of glutamine supplementation on intensity of precived pain and Creatine Kinase after eccentric contraction in untrained men. Eighteen healthy men (age: 22. 35 ±2. 27 yr; body mass: 69. 91 ±9. 78 kg; height: 177. 08 ±4. 32 cm) were matched and randomized; double-blind study with subjects assigned to either an L-glutamine supplementation (n=10) or placebo (n=8) group. The subjects in two groups were asked to take three times in week for 4 weeks. Each subject was screened for dietary habits before inclusion into the study. Participants performed 6 set to exhaustion eccentric leg extensions at 75% of 1RM and rest intervals were 3 minute among sets. Creatine Kinase and perceived muscle soreness measurements were taken before exercise protocol and 24 and 48 h afterwards. There was no statistically significant difference between groups in Creatine Kinase. Nonetheless، glutamine ingestion 24 and 48 hour after the eccentric exercise، Significant decreases were observed in muscle pain (P < 0. 05). The results indicate that glutamine supplementation has no significant effect on muscle injury markers (Creatine Kinase) in between groups، but ingestion of glutamine can be effective in ameliorating muscle pain induced by eccentric exercise in between groups.