The Effect of Berberine Hydrochloride on Motor Function Impairment in Streptozotocin- Induced Diabetic Rats
Author(s):
Abstract:
Introduction
Ddiabetes induce motor function impairment. Berberine is an isoquinoline alkaloid that has multiple pharmacological effects including anti-diabetic and antioxidant activity. Methods
40 male wistar rats were randomly selected and allocated to 5 equal groups: Control, Control berberine-treated (100 mg/kg), diabetic, and berberine- treated diabetic (50, 100 mg/kg). Diabetes was induced by STZ administration at the dose of 55 mg/ kg through i.p. route. Berberine hydrochloride was administered p.o. at doses of 50 and 100 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein in 1, 3, 5, and 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including y maze task, inclend plane and barfix were performed at the end of 6th and 7th weeks. Results
diabetic Berberine-treated groups (50, 100 mg/kg/day) has significant improvement rather than diabetic group in inclend plane test and y maze task.Conclusion
Berberine hydrochloride administration for 6 weeks improves motor function impairment in streptozotocin- induced diabetic rats.Keywords:
Language:
Persian
Published:
Journal of Knowledge & Health, Volume:8 Issue: 4, 2013
Page:
181
https://magiran.com/p1209922
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!