Detection of CXCL5 Gene Polymorphism with Diabetes in Ardabil Province

CXCL5، also known as epithelial cell-derived neutrophilactivating peptide (ENA-78)، is a chemokine that has a role in some diseases. CXCL5 blocks insulin signaling by activating the Jak2/STAT5/SOCS2 pathway. It is reported the association between -156G>C (rs352046) polymorphism in the promoter region and diabetes. The aim of this study was to examine whether there is an association between this polymorphism and diabetes mellitus in Ardabil province population. A total of 100 patients affected diabetes were recruited from Ardabil province population; 100 healthy control subjects also were recruited from the same area. The region containing the CXCL5 - 156G>C polymorphism was genotyped by PCR amplification and restriction fragment length polymorphism analysis، and allele frequency data were analyzed using Fisher test. The results show a higher frequency of carrying both the G/G and G/C genotype in patients with diabetes compared with healthy controls (p-value=0. 01 and 0. 006، respectively). In addition، the frequency of allele C was significantly increased (p-value = 0. 028) in patients with diabetes (25. 5%) compared with controls (12%). Our findings suggest a role of CXCL5 in the pathogenesis of diabetes. Also، replications in other populations with larger sample sizes are required to confirm these findings.