The effect of endurance training and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus

This study was to examine the effects of endurance training and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus. Twenty eight Wistar rats were divided into four groups: (1) Regular diet-sedentary (RD-Sed)، (2) Regular diet-Exercise (RD-Exe)، (3) HF-sedentary (HF-Sed)، and (4) HF- Exercise (HF- Exe); RD-Sed group was regarded as control. Animals in exercise groups received 8-wk endurance training and animals in HF groups were exposed to the HF diet for 8-wk. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at P<0. 05. The results showed that the endurance training had no significant increase in BDNF protein level comparison with the RD-Sd and HF-Sed groups; moreover the high-fat diet had no significant effect in BDNF protein level. According to results of present study، looks applications of endurance training can increase amount of hippocampus BDNF protein level.