Herpes Simplex Virus Meningitis in Children in South East of Caspian Sea, Iran
Author(s):
Abstract:
Background
Herpes simplex virus (HSV) is a member of Herpesviridae and a leading cause of human viral diseases. Meningitis occurs as a complication of HSV-1 or HSV-2 primary infection.. Objectives
We aimed to evaluate HSV meningitis in children in Gorgan province, Iran.. Patients and Methods
Forty-five cerebrospinal fluid samples were taken from children referred with meningitis symptoms. Samples with negative bacterial culture results were tested for viral, biochemical and cytological assays. DNA extraction and PCR were performed.. Results
HSV-1 detected in 4 (8.8%) samples without any HSV-2 infections. Cases with positive results had fever and CSF pleocytosis. Vomiting, headache and higher count of WBC were observed in 3, 2 and 3 cases respectively. The cerebrospinal fluid (CSF) glucose and protein levels were normal and 3 cases showed positive C-reactive protein (CRP) results. Also erythrocyte sedimentation rate (ESR) was higher than normal in all positive cases..Conclusions
Distribution of HSV types in children with meningitis in our area predominantly was type 1 compared with type 2, which has been reported more in other area..Keywords:
HSV , Meningitis , CSF , PCR , Children
Language:
English
Published:
Jundishapur Journal of Microbiology, Volume:7 Issue: 1, Jan 2014
Page:
8599
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