Evaluation of Candida Infection after Six Months of Transplantation in Pediatric Liver Recipients in Iran

Message:
Abstract:
Background
Liver transplantation (LT) is the standard treatment of end-stage liver diseases (ESLD). Invasive fungal infection is one of the important causes of morbidity and mortality after transplantation.
Objective
To determine the incidence of late-onset (after 6 months of LT) Candida infection in recipients.
Methods
A retrospective study was conducted to evaluate 50 pediatric patients after LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We followed the patients until 6 months post-LT for episodes of Candida infection proven by culture.
Results
One recipient (2%) developed late-onset esophageal candidiasis with improvement after intravenous amphotricin therapy but finally expired with a diagnosis of post-transplant lymphoproliferative disorder (PTLD).
Conclusions
The incidence of late-onset Candida infection is not significant in pediatric liver recipient, but it still remains a significant problem. Control of Candida colonization would reduce the risk of invasive fungal infections and possibly more fatal complications.
Language:
English
Published:
International Journal of Organ Transplantation Medicine, Volume:2 Issue: 3, Summer 2011
Page:
105
https://magiran.com/p1245383  
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