Effects of Gentamicin on Rabbit Newborn Spermatic Cords

In this study، the teratogenic effects of Gentamicin on newborn spermatic cords of rabbits whose mothers received this medication during pregnancy is investigated. The experimental study was done on forty rabbits 6-month old that were divided into 4 groups of 10 (8 females and 2 males) and polygamously impregnated. 1. 7/mg/kg dosage Gentamicin injections were done in gluteal muscles of pregnanted rabbits in the following groups: 1. control (did not receive any medication)، 2. predifferentiation (from 1th to 8th pregnancy days)، 3. embryogenic period (from 9th to 16th) and 4. fetal period (from 20th to 27th) for 8 days. After birth، three days old male newborns testes were dissected. Samples were stained using H&E method and light microscopy studies were done. Gentamicin injection to pregnant mother before embryonic differentiation was caused canalization of spermatic cords and their conversion to seminiferous tubules in newborn. Also embryonic stage injection increased seminiferous tubules diameter، but was not observed any changes in newborn whose mother had received medication in embryonic Predifferentiation. Results showed that using Gentamicin for pregnancy infection treatment especially before differentiation and embryonic stages were effective on rabbit newborn spermatic cords morphogenesis and caused early maturation.