Diazinon alters sex hormones, Interferon-gamma, Interleukin-4 and 10 in male Wistar rats

Agricultural toxins including organochlorine and organophosphorus families cause damages in the various tissues in humans. Diazinon is a non-systemic organophosphate insecticide. This study was carried out to determine the effect of Diazinon on sex hormone، interferon gamma، interleukin-4 and 10 in male rats. In this experimental study 24 adult male Wistar rats were randomly allocated into four groups. Three experimental groups were received Diazinon 5 days per week for one month at 0. 3، 3 and 30 mg/kg/bw intraperitoneally، while controls received nothing. Seven days after the last injection، blood samples were obtained and the serum testosterone، FSH، LH، interferon gamma، interleukin-4 and interleukin-10 were measured. Serum level of Interleukin-10 significantly increased in experimental group (30 mg/kg/bw of Diazinon) compared to controls (P<0. 05). Serum level of Interleukin-10 significantly decreased in 0. 3 mg/kg/bw and 3mg/kg/bw of Diazinon groups compared to controls (P<0. 05). Interleukin-4 level was only significant in the group receiving 30 mg/kg/bw of Diazinon (P<0. 05). Reduction in interferon-gamma level was not significant between control and experimental groups. FSH significantly reduced in the three experimental groups in comparison with controls (P<0. 05). Testosterone level was significantly increased in experimental groups compared to control (P<0. 05). Diazinon increases interleukin-10 and testosterone and reduces FSH hormone in the rat.