Effect of Apium Graveolens on Testis and Spermatogenesis in Mice

The scientific name of the dark mountain celery is Apium graveolens. This plant contains phytoestrogens and has many effects on the reproductive system. In this study, hydroalcoholic leaf extract on the testicular tissue and spermatogenesis in male mice was investigated. The samples were randomly divided into 5 groups (three treatment groups, placebo and control groups), and all samples were stored in the same condition. Apium leaves hydroalcoholic extract in different doses (mg/kg/2day150, 100, 50) was injected (IP) into the treated groups for 20 days (one day in between). The Placebo groups were used for injection of saline. The parameters that were evaluated changes, testicular weight and histology of spermatogenesis was compared with control groups. Data were analyzed by SPSS software and statistical tests one way ANOVA and Duncan test. This study showed dose-dependent negative effect of Apium extract on spermatogenesis and reproductive potential in male rats.