The Investigation of silymarin effect on colon ulcer induced acetic acid in mice Balb/C

Colonulcer is an inflammatory chronic colon disease and free radicals play an important role in its pathogenesis. Free radicals increase the severity of the disease by decreasing the antioxidants. Silymarin is a flavonoid component that it's extracted of Silybum marianum. Silymarin contains antioxidants and inhibits the inflammatory reactions. The aim of this research is the investigation of anti- inflammatory effect of silymarin in the treatment of colon ulcer induced acetic acid in mice Balb/C spicies.In this study, 32 mice are divided into 4 groups (n=8).These groups include:control group with no colitis report, the Sham group with colitis report that are not treated and the groups with colitis report that received 10 20 mg/kg B.W. of silymarin orally.The treatment groups received silymarin daily, for 1 week after having the disease. The drugs are fed to the mice per oral using gaster tubes. To induce colitis, 1 ml of acetic acid (%4) is injected into the rectum. In the one week after induction of colitis, the animals sacrificed and the damages of the colon investigated in Morris and Murthy methods. The result of this study shown acetic acid causes severe inflammation and damages of the colon. Because colit ulcerative is an acute disease so, use of silymarin is effective in improving of the inflammation and repair of the colon ulcer induced acetic acid. So, use of silymarin can be considered as a way for the treatment.