Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid
Author(s):
Yamin Yan , Qiaoling Fan , Aiqiu Li , Jialing Chen , Feifei Dong , Mei Gong
Abstract:
Objective
To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates.Methods
The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1st, 2010 and May 1st, 2012 were analyzed retrospectively. The treatment procedure for drug extravasation adhered to the protocol in neonatal department. The information including age, sex, weight, diagnosis, size of affected area, site of extravasation and treatment was collected.Findings
The extravasation injuries alleviated and the symptoms improved after treatment, no adverse drug effects were reported with use of hyaluronidase and hirudoid.Conclusion
The treatment appeared to be beneficial in the management of extravasations of various medications in neonates and may be useful in reducing the severity of cutaneous toxicosis. However, further studies with large samples are still needed to assess the effectiveness and safety of hyaluronidase and hirudoid.Keywords:
Language:
English
Published:
Iranian Journal of Pediatrics, Volume:24 Issue: 4, Aug 2014
Pages:
352 to 358
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