The hemostatic effect of aluminum sulfate in liver bleeding in rat

Despite great advances in the field of surgery, the control of liver parenchymal hemorrhage is still one of the challenges surgeons face in saving the patients’ lives. Aluminum sulfate is used as a hemostatic agent in dental surgery. This study aimed to examine the hemostatic effect of aluminum sulfate on controlling bleeding from liver parenchymal tissue. In this experimental study, 60 male Wistar rats were randomly allocated into six equal groups of 10 mice each. An incision (2 cm length; 0.5 cm depth) was made on each rat's liver surface and the length of time to hemostasis as a dependent variable was measured using different concentrations of aluminum sulfate (5%, 10%, 15%, 25%, and 50%) against the control method (control of bleeding by suturing) as the independent variable. The liver tissue was examined for pathological changes. The length of time to hemostasis in the aluminum sulfate groups was significantly less than that of the control group (P<0.01). The pathologic examination showed the highest frequency of low-grade inflammation based on the defined pathological grading. Aluminum sulfate is an effective hemostatic agent with low-grade inflammation effect in controlling the bleeding from liver parenchymal tissue in an animal model.