Novel Potentiometric Determination of Torasemide for Antidoping Purpose, Using β-Cyclodextrin and Calixarene

Two novel Torasemide (TOR) sensors were investigated, using β-cyclodextrin and calix[4]arene as ionophores, where linear responses within concentration ranges of (10-7 10-2 and 10-8-10-2M) and Nernstian slopes of (58.77 and 59.214 mV/decade) over the pH range of 7-12 were obtained, respectively.The selectivity coefficients of the developed sensors indicate excellent selectivity for TOR, where the second sensor shows a higher sensitivity if compared to the first one. The proposed fabricated sensors display useful analytical characteristics for the determination of TOR (for anti-doping purpose) in bulk powder, biological fluids and in pharmaceutical formulation.