Effect of vaginal misoprostol on pregnancy rate after intrauterine insemination: a randomized controlled trial

Intrauterine insemination (IUI) is one of the most appropriate and cost-effective methods in infertility treatment.

We aimed to investigate effect of vaginal misoprostol on pregnancy rate after IUI.

Two hundred and ten infertile women who were referred to Infertility Clinic of Alzahra Hospital by an indication of IUI during 2012-2013 were randomly assigned to receive 200 μg vaginal misoprostol (n=105) or vaginal placebo (n=105) after IUI. For detecting pregnancy, past 2 weeks, beta human chorionic gonadotropin evaluation was made and if positive, transvaginal sonography was done for evaluation of pregnancy 2-3 weeks later and clinical pregnancy was recorded.

Pregnancy had been noted in 24 patients in misoprotol (22.9%) and 27 patients in placebo (25.7%) groups that this difference was not significant (p=0.748). In misoprostol group, 3 case of nausea and vomiting (2.9%) had been observed.

According to the results, administering 200 μg vaginal misoprostol after IUI doesn’t have significant effect on the success rate of IUI