Determination of Mycobacterium tuberculosis resistance to anti tuberculous drugs and influencing factors on samples referred to Shariati hospital in Mashhad in 2012-2013

Nowadays, one of the main problems of tuberculous treatment is drug resistance. Present study was designed to determine drug resistance of mycobacterium isolated from patients with pulmonary tuberculosis to anti-tuberculous drugs and to detect the influencing factors. In a cross-sectional study in 2012-2013, all smear positive sputum)125 samples) cultured and their anitibiogram were done in tuberculous laboratory of Shariati Hospital. Provided checklists were filled with corporation of Vicechancellor Mashhad University of Medical Science of and Mashhad Health Centers and other towns of province. Then by using SPSS software, resistance rate and influencing factors were evaluated. In this study the rate of resistance to Isoniazid was 7%, to Rifampin 7%, to Ethambutol 3.9%, to Streptomycin 11.8%, to Isoniazid and Rifampin (MDR-TB) 4%,. The highest rate of resistance was observed in 15-45 years-age group. Statistically, a close-to-significant relationship was observed between incidence of resistance and two factors including recurrence and grade of smear positivity. Results obtained for 20% of total cultured samples were non tuberculous Mycobacterium (NTM). Considering the MDR TB prevalence in Khorasan, DOTS strategy had to be carried out completely and appropriately to prevent incidence of more resistance cases. Considering the high rate of NTM, was has proposed that when diagnosing tuberculosis, culture and antibiogram had to be implemented for all patients to prevent tuberculosis aberrant treatment, that cause increasing resistance to drugs, and to give appropriate treatment for such patients at initial stages. Acknowledgment: This is no conflict of interest