Comparing the effect of flaxseed oil with vitamin E on non-invasive markers of liver in patients with nonalcoholic fatty liver disease

Omega-3 polyunsaturated fatty acids have proven effects on hyperlipidemia and cardiovascular diseases. Given that there is no single consensus on the treatment of NAFLD and high levels of Omega-3 is found in flax seed oil and in this regard no study has been done in the world, we decided to evaluate the effects of flaxseed oil on non-invasive markers of fatty liver. In a randomised controlled trial, 60 participants with NAFLD were randomised to 2 months treatment with either Flaxseed or vitamin E(in two groups each 30).Weight, body mass index, waist circumference, liver enzymes, blood glucose, insulin and lipid profiles were measured before and after the intervention. In flax seed oil group ALT, AST, ALP (alkaline phosphatase)., TG (triglyceride)., Insulin was decreased and HDL (High density lipoprotein). Were increased significantly(P<0.05)..In vitamin E group, only the level of AST, ALT and total bilirubin was significantly decreased. (P<0.05). Flaxseed oil is effective and safe in the improvement of non-invasive liver markers of patients with NAFLD. However, further studies with a larger sample size are needed to confirm the efficacy and safety of this drug.