Nonsyndromic Synchronous Multifocal Central Giant Cell Granulomas of the Maxillofacial region: Report of a Case

Central giant cell granuloma (CGCG) is a benign proliferation of fibroblasts and multinucleated giant cells that almost exclusively occurs within the jaws. It commonly occurs in young adults showing a female predilection in anterior mandible. Multifocal CGCGs in maxillofacial region are very rare and suggestive of systemic diseases such as hyperparathyroidism, an inherited syndrome such as Noonan-like multiple giant cell lesion syndrome or other disorders. Only 10 cases of multifocal CGCGs in maxillofacial region without any concomitant systemic diseases have been currently reported in English literature. We report here an unusual case of 36 year old female who presented with nonsyndromic synchronous, multifocal CGCGs in left posterior mandible and left posterior maxilla without any concomitant systemic disease. Literature regarding the same is reviewed and the incidence, clinical features, radiological features, differential diagnosis and management of CGCGs are discussed.