The effect of different types of exercise training on brain-derived neurotrophic factor in the rat

This study aimed to identify the possible effects of the different types of exercise on levels of brain-derived neurotrophic factor (BDNF-Brain-Derived Neurotrophic Factor) in the hippocampus of adult rats. In this experimental-trail، Thirty-five Wistar rats were divided into five groups: (1) Sedentary (Sed)، (2) Endurance Training (ET)، (3) High-Intensity Interval Training (HIIT)، Sprint Training (ST)، Incline Treadmill Workout (ITW); Sed group was regarded as control. ET group received 8-wk Mild-intensity endurance exercise. The exercise schedule of HIIT group consisted of high intensity interval training for 8 weeks (with Active recovery). ST group ran on treadmill for 8-weeks with high intensity. ITW group ran on the inclined treadmill. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at α<0. 05. The results showed that all training groups had no significant differ in BDNF protein level comparison with the Sd group (PET=0. 786، PHIIT= 0. 135، PST= 0. 163، PITW=0. 172). However، altered exercise training did not differ significantly BDNF levels، it seems، higher intensity exercise and stress can affect more change in hippocampus BDNF levels.