Effects of alcoholic extract of walnut's leaves (Juglans regia L.) on the blood's biochemical factors of diabetic rats

In this investigation، the effects of alcoholic extract administration of walnut''s leaves (Juglans regia L.) on the serum levels of glucose، urea، triglyceride and cholesterol of diabetic rats were studied. Alcoholic extract of walnut''s leaves was prepared by maceration technique and then their lethal dose was measured. From 32 male and female rats، 8 rats were considered as control (non diabetic) and the others were made diabetic by subcutaneous injection of 120mg/kg body weight Alloxan monohydrate. Diabetic rats were divided into experimental groups as follows: 1 (with no treatment)، 2 (treated with 0. 75g/kg body weight alcoholic extract) and 3 (treated with 0. 5 g/kg body weight of alcoholic extract). Blood samples were collected weekly for a period of four weeks and the serum levels of glucose، urea، triglyceride and cholesterol were measured. The results indicated that the administration of extract might lower the serum levels of glucose and urea and increase the serum levels of cholesterol and triglyceride.