Comparison the effect of casein phosphopeptide amorphous calcium phosphate and fluoride varnish on dentin hypersensitivity reduction

Nowadays, several casein components such as casein phosphopeptide amorphous calcium phosphate (CPP-ACP) are vastly considered as a suitable replacement for fluoride component. The aim of this study was to compare the effect of CPP-ACP paste and fluoride varnish on dentin hypersensitivity reduction. In this clinical trial study, thirty adult patients between the ages of 20-50 years, presenting with the chief complaint of dentin hypersensitivity were examined. The loss of dentin was less than 0.5mm. The subjects divided into three groups: In groups I and II, patients were treated using CPP-ACP and fluoride varnish following manufacturer instructions. Group III received placebo gel. A visual analog scale was used to assess subject's response to compressed air and ice stimuli at baseline, 7 days, 28 days and 60 days after treatment. Data was analyzed by One Way Analysis of Variance (ANOVA), Duncan Post Hoc test using the SPSS software version 21. The results showed significant statistical difference between the groups (P<0.05). In fluoride varnish group and CPP-ACP paste group, the dentin hypersensitivity significantly decreased when baseline scores compared to post treatment scores at 7, 28, 60 days (P<0.05). There was no significant statistical difference in dentin hypersensitivity reduction in fluoride varnish and CPP-ACP paste groups. The results of this study showed that both of fluoride varnish and CPP-ACP paste effectively reduced dentinal hypersensitivity compared with placebo-control group.